Chlorotoxin-functionalized mesoporous silica nanoparticles for pH-responsive paclitaxel delivery to Glioblastoma multiforme

Chlorotoxin-functionalized mesoporous silica nanoparticles for pH-responsive paclitaxel delivery to Glioblastoma multiforme

Glioblastoma multiforme (GBM) is a highly aggressive brain cancer associated with poor survival rates. We developed novel mesoporous silica nanoparticles (MSNs)-based nanocarriers for pH-responsive delivery of a therapeutic drug Paclitaxel (PTX) to GBM tumor cells. The pores of MSNs are loaded with...

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Bibliographic Details
Main Authors: Mirjana Mundžić, Amelia Ultimo, Minja Mladenović, Aleksandra Pavlović, Oliviero L. Gobbo, Eduardo Ruiz-Hernandez, Maria Jose Santos-Martinez, Nikola Ž. Knežević
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Mesoporous silica nanoparticles
Paclitaxel
Glioblastoma multiforme
Targeted drug delivery
pH-responsive
Cyclodextrin
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024171824
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http://www.sciencedirect.com/science/article/pii/S2405844024171824

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