Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise
Objective. To assess the influence of different physical training status on exercise-induced oxidative stress and changes in cellular redox state. Methods. Thirty male subjects participated in this study and were assigned as well-trained (WT), moderately trained (MT), and untrained (UT) groups. The...
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| Language: | English |
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Wiley
2016-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2016/3757623 |
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| author | Farnaz Seifi-skishahr Arsalan Damirchi Manoochehr Farjaminezhad Parvin Babaei |
| author_facet | Farnaz Seifi-skishahr Arsalan Damirchi Manoochehr Farjaminezhad Parvin Babaei |
| author_sort | Farnaz Seifi-skishahr |
| collection | DOAJ |
| description | Objective. To assess the influence of different physical training status on exercise-induced oxidative stress and changes in cellular redox state. Methods. Thirty male subjects participated in this study and were assigned as well-trained (WT), moderately trained (MT), and untrained (UT) groups. The levels of cortisol, creatine kinase, plasma reduced glutathione to oxidized glutathione (GSH/GSSG), cysteine/cystine (Cys/CySS), and GSH/GSSG ratio in red blood cells (RBCs) were measured immediately and 10 and 30 min after exercise. Results. Following the exercise, plasma GSH/GSSG (p=0.001) and Cys/CySS (p=0.005) were significantly reduced in all groups. Reduction in plasma GSH/GSSG ratio in all groups induced a transient shift in redox balance towards a more oxidizing environment without difference between groups (p=0.860), while RBCs GSH/GSSG showed significant reduction (p=0.003) and elevation (p=0.007) in UT and MT groups, respectively. The highest level of RBCs GSH/GSSG ratio was recorded in MT group, and the lowest one was recorded in the WT group. Conclusion. Long term regular exercise training with moderate intensity shifts redox balance towards more reducing environment, versus intensive exercise training leads to more oxidizing environment and consequently development of related diseases. |
| format | Article |
| id | doaj-art-db5e0bb45d284381915ad5081bcfc143 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-db5e0bb45d284381915ad5081bcfc1432025-02-03T05:50:21ZengWileyBiochemistry Research International2090-22472090-22552016-01-01201610.1155/2016/37576233757623Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic ExerciseFarnaz Seifi-skishahr0Arsalan Damirchi1Manoochehr Farjaminezhad2Parvin Babaei3Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, IranDepartment of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, IranMedicinal Plants Research Center, Ardabil Branch, Islamic Azad University, Ardabil, IranDepartment of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, IranObjective. To assess the influence of different physical training status on exercise-induced oxidative stress and changes in cellular redox state. Methods. Thirty male subjects participated in this study and were assigned as well-trained (WT), moderately trained (MT), and untrained (UT) groups. The levels of cortisol, creatine kinase, plasma reduced glutathione to oxidized glutathione (GSH/GSSG), cysteine/cystine (Cys/CySS), and GSH/GSSG ratio in red blood cells (RBCs) were measured immediately and 10 and 30 min after exercise. Results. Following the exercise, plasma GSH/GSSG (p=0.001) and Cys/CySS (p=0.005) were significantly reduced in all groups. Reduction in plasma GSH/GSSG ratio in all groups induced a transient shift in redox balance towards a more oxidizing environment without difference between groups (p=0.860), while RBCs GSH/GSSG showed significant reduction (p=0.003) and elevation (p=0.007) in UT and MT groups, respectively. The highest level of RBCs GSH/GSSG ratio was recorded in MT group, and the lowest one was recorded in the WT group. Conclusion. Long term regular exercise training with moderate intensity shifts redox balance towards more reducing environment, versus intensive exercise training leads to more oxidizing environment and consequently development of related diseases.http://dx.doi.org/10.1155/2016/3757623 |
| spellingShingle | Farnaz Seifi-skishahr Arsalan Damirchi Manoochehr Farjaminezhad Parvin Babaei Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise Biochemistry Research International |
| title | Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise |
| title_full | Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise |
| title_fullStr | Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise |
| title_full_unstemmed | Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise |
| title_short | Physical Training Status Determines Oxidative Stress and Redox Changes in Response to an Acute Aerobic Exercise |
| title_sort | physical training status determines oxidative stress and redox changes in response to an acute aerobic exercise |
| url | http://dx.doi.org/10.1155/2016/3757623 |
| work_keys_str_mv | AT farnazseifiskishahr physicaltrainingstatusdeterminesoxidativestressandredoxchangesinresponsetoanacuteaerobicexercise AT arsalandamirchi physicaltrainingstatusdeterminesoxidativestressandredoxchangesinresponsetoanacuteaerobicexercise AT manoochehrfarjaminezhad physicaltrainingstatusdeterminesoxidativestressandredoxchangesinresponsetoanacuteaerobicexercise AT parvinbabaei physicaltrainingstatusdeterminesoxidativestressandredoxchangesinresponsetoanacuteaerobicexercise |