Assessment of Single‐Cycle M‐Protein Mutated Vesicular Stomatitis Virus as a Safe and Immunogenic Mucosal Vaccine Platform for SARS‐CoV‐2 Immunogen Delivery

Assessment of Single‐Cycle M‐Protein Mutated Vesicular Stomatitis Virus as a Safe and Immunogenic Mucosal Vaccine Platform for SARS‐CoV‐2 Immunogen Delivery

Abstract The goal of the next‐generation COVID‐19 vaccine is to provide rapid respiratory tract protection with a single dose. Circulating antibodies do not protect the olfactory mucosa from viral infection, necessitating localized mucosal immunization. Live attenuated vesicular stomatitis virus (VS...

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Bibliographic Details
Main Authors: En Zhang, Yong Ke, Weihong Ran, Yu Zhang, Ruihang Li, Xinkui Fang, Lei Wang, Baohong Zhang, Tao Sun
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
COVID‐19
mucosal immunity
replication defective
Spike protein
vesicular stomatitis virus
Online Access:https://doi.org/10.1002/advs.202404197
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https://doi.org/10.1002/advs.202404197

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