Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication

Foot-and-mouth disease virus activates glycolysis and hijacks HK2 to inhibit innate immunity and promote viral replication

Abstract Foot-and-mouth disease (FMD) severely restricts the healthy development of global animal husbandry, and the unclear pathogenic mechanism of FMD virus (FMDV) leads to difficulty in preventing and purifying FMD. Glycolytic remodelling is considered one of the hallmarks of viral infection, pro...

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Main Authors: Wenxian Chen, Xinyan Wang, Xiaowen Li, Weijun Wang, Yaoyao Huang, Yuwei Qin, Pengfei Liu, Keke Wu, Bingke Li, Yintao He, Sen Zeng, Lin Yi, Lianxiang Wang, Mingqiu Zhao, Hongxing Ding, Shuangqi Fan, Zhaoyao Li, Jinding Chen
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Veterinary Research
Subjects:
Foot-and-mouth disease virus
glycolysis
hexokinase 2
replication
interferon regulatory factor
Online Access:https://doi.org/10.1186/s13567-025-01497-w
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https://doi.org/10.1186/s13567-025-01497-w

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