SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity
Over the past several years, SIRT5 has attracted considerable attention in metabolic regulation. However, the function of SIRT5 in tumorigenesis by regulating tumor microenvironment is poorly understood. In this work, we found that Sirt5 knockout mice were resistant to AOM and DSS-induced colitis-as...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3792409 |
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| author | Ke Wang Zuojian Hu Cuiping Zhang Lujie Yang Li Feng Pengyuan Yang Hongxiu Yu |
| author_facet | Ke Wang Zuojian Hu Cuiping Zhang Lujie Yang Li Feng Pengyuan Yang Hongxiu Yu |
| author_sort | Ke Wang |
| collection | DOAJ |
| description | Over the past several years, SIRT5 has attracted considerable attention in metabolic regulation. However, the function of SIRT5 in tumorigenesis by regulating tumor microenvironment is poorly understood. In this work, we found that Sirt5 knockout mice were resistant to AOM and DSS-induced colitis-associated colorectal tumorigenesis and the level of IFN-γ in their tumor microenvironment was higher. Additionally, proteome and network analysis revealed that SIRT5 was important in the T cell receptor signaling pathway. Furthermore, we determined that a deficiency of Sirt5 induced stronger T cell activation and demonstrated that SIRT5 played a pivotal role in regulating the differentiation of CD4+ regulatory T (Treg) cells and T helper 1 (Th1) cells. An imbalance in the lineages of immunosuppressive Treg cells and the inflammatory Th1 subsets of helper T cells leads to the development of colon cancer. Our results revealed a regulatory role of SIRT5 in T cell activation and colorectal tumorigenesis. |
| format | Article |
| id | doaj-art-db3fdfd9ca3846a1aff4b28577d74007 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-db3fdfd9ca3846a1aff4b28577d740072025-02-03T06:45:48ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/37924093792409SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell ActivityKe Wang0Zuojian Hu1Cuiping Zhang2Lujie Yang3Li Feng4Pengyuan Yang5Hongxiu Yu6Institutes of Biomedical Sciences & Minhang Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi, ChinaInstitutes of Biomedical Sciences & Minhang Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaInstitutes of Biomedical Sciences & Minhang Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaInstitutes of Biomedical Sciences & Minhang Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaInstitutes of Biomedical Sciences & Minhang Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaInstitutes of Biomedical Sciences & Minhang Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaOver the past several years, SIRT5 has attracted considerable attention in metabolic regulation. However, the function of SIRT5 in tumorigenesis by regulating tumor microenvironment is poorly understood. In this work, we found that Sirt5 knockout mice were resistant to AOM and DSS-induced colitis-associated colorectal tumorigenesis and the level of IFN-γ in their tumor microenvironment was higher. Additionally, proteome and network analysis revealed that SIRT5 was important in the T cell receptor signaling pathway. Furthermore, we determined that a deficiency of Sirt5 induced stronger T cell activation and demonstrated that SIRT5 played a pivotal role in regulating the differentiation of CD4+ regulatory T (Treg) cells and T helper 1 (Th1) cells. An imbalance in the lineages of immunosuppressive Treg cells and the inflammatory Th1 subsets of helper T cells leads to the development of colon cancer. Our results revealed a regulatory role of SIRT5 in T cell activation and colorectal tumorigenesis.http://dx.doi.org/10.1155/2020/3792409 |
| spellingShingle | Ke Wang Zuojian Hu Cuiping Zhang Lujie Yang Li Feng Pengyuan Yang Hongxiu Yu SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity Journal of Immunology Research |
| title | SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity |
| title_full | SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity |
| title_fullStr | SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity |
| title_full_unstemmed | SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity |
| title_short | SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity |
| title_sort | sirt5 contributes to colorectal cancer growth by regulating t cell activity |
| url | http://dx.doi.org/10.1155/2020/3792409 |
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