Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid
Various 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and eval...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/924734 |
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| author | Sabir Hussain Jyoti Sharma Mohd Amir |
| author_facet | Sabir Hussain Jyoti Sharma Mohd Amir |
| author_sort | Sabir Hussain |
| collection | DOAJ |
| description | Various 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and evaluated for their antibacterial and antifungal activity. The compounds showed significant antibacterial activity against S. aureus (gram-positive) and E.coli (gram-negative) bacteria and antifungal activity against A. niger fungi using cup plate technique |
| format | Article |
| id | doaj-art-db2efb901ac44b4cbafa893cd3816d55 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-db2efb901ac44b4cbafa893cd3816d552025-02-03T01:09:22ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015496396810.1155/2008/924734Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic AcidSabir Hussain0Jyoti Sharma1Mohd Amir2Department of Chemistry, R. R. College, Alwar, Rajasthan, IndiaDepartment of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, IndiaDepartment of Chemistry, R. R. College, Alwar, Rajasthan, IndiaVarious 4-amino-2-[4-(4-substituted phenyl)-5-sulfanyl-4H-1,2,4-triazol-3-yl] phenol (4a-c), 4-amino-2-{4-amino-5-[(4-substituted phenyl)amino]-4H-1,2,4-triazol-3-yl} phenol (5a-c) and 4-amino-2-{5-[(4-substituted phenyl)amino]-1,3,4-thiadiazole-2-yl} phenol (6a-g) were synthesized and evaluated for their antibacterial and antifungal activity. The compounds showed significant antibacterial activity against S. aureus (gram-positive) and E.coli (gram-negative) bacteria and antifungal activity against A. niger fungi using cup plate techniquehttp://dx.doi.org/10.1155/2008/924734 |
| spellingShingle | Sabir Hussain Jyoti Sharma Mohd Amir Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid E-Journal of Chemistry |
| title | Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid |
| title_full | Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid |
| title_fullStr | Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid |
| title_full_unstemmed | Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid |
| title_short | Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid |
| title_sort | synthesis and antimicrobial activities of 1 2 4 triazole and 1 3 4 thiadiazole derivatives of 5 amino 2 hydroxybenzoic acid |
| url | http://dx.doi.org/10.1155/2008/924734 |
| work_keys_str_mv | AT sabirhussain synthesisandantimicrobialactivitiesof124triazoleand134thiadiazolederivativesof5amino2hydroxybenzoicacid AT jyotisharma synthesisandantimicrobialactivitiesof124triazoleand134thiadiazolederivativesof5amino2hydroxybenzoicacid AT mohdamir synthesisandantimicrobialactivitiesof124triazoleand134thiadiazolederivativesof5amino2hydroxybenzoicacid |