Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report
Xinxin Wo, Xiaoyan Yu, Lingling Miao, Yushan Mao, Keke Tang Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of ChinaCorrespondence: Keke Tang, Department of Endocrinology, The First Affiliated Hospital of Ningbo University...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-01-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/diabetic-ketoacidosis-in-klinefelter-syndrome-sans-malignancy-with-unu-peer-reviewed-fulltext-article-DMSO |
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| Summary: | Xinxin Wo, Xiaoyan Yu, Lingling Miao, Yushan Mao, Keke Tang Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of ChinaCorrespondence: Keke Tang, Department of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, People’s Republic of China, Email lcyxtkk@126.comPurpose: Klinefelter’s syndrome (KS) is the most common sex chromosome disorder in the male population and is characterized by the presence of one or more X chromosomes. Studies have reported that the proportion of KS patients with diabetes is not low. It is also not uncommon for diabetes patients with poorly controlled blood glucose to have a transient mild increase in their carcinoembryonic antigen (CEA) levels. This study reports the case of Diabetic ketoacidosis (DKA) concurrently with a significant increase in CEA levels (reaching 40.8 ng/mL) in patients with KS.Methods: This middle-aged KS patient was immediately treated for DKA upon admission. A series of exams were performed to exclude the possibility of malignant tumors, and the patient’s glucose and CEA levels were closely monitored.Results: After excluding the possibility of malignant tumors, the patient’s CEA level gradually decreased to normal after good glycemic control.Conclusion: This is the first report describing significant increases in CEA levels in KS patients with diabetes, which is of great clinical significance for the treatment of diabetes patients.Keywords: diabetic ketoacidosis, hyperglycemia, Klinefelter’s syndrome, carcinoembryonic antigen |
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| ISSN: | 1178-7007 |