Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells
Recurrence of breast cancer after radiotherapy may be partly explained by the presence of radioresistant cells. Thus, it would be desirable to develop an effective therapy against radioresistant cells. In this study, we demonstrated the intense antitumor activity of cytokine-induced killer cells aga...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695961 |
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| _version_ | 1849397460078690304 |
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| author | Qingming Guo Danni Zhu Xiaocui Bu Xiaofang Wei Changyou Li Daiqing Gao Xiaoqiang Wei Xuezhen Ma Peng Zhao |
| author_facet | Qingming Guo Danni Zhu Xiaocui Bu Xiaofang Wei Changyou Li Daiqing Gao Xiaoqiang Wei Xuezhen Ma Peng Zhao |
| author_sort | Qingming Guo |
| collection | DOAJ |
| description | Recurrence of breast cancer after radiotherapy may be partly explained by the presence of radioresistant cells. Thus, it would be desirable to develop an effective therapy against radioresistant cells. In this study, we demonstrated the intense antitumor activity of cytokine-induced killer cells against MCF-7 and radioresistant MCF-7 cells, as revealed by cytokine-induced killer–mediated cytotoxicity, tumor cell proliferation, and tumor invasion. Radioresistant MCF-7 cells were more susceptible to cytokine-induced killer cell killing. The stronger cytotoxicity of cytokine-induced killer cells against radioresistant MCF-7 cells was dependent on the expression of major histocompatibility complex class I polypeptide–related sequence A/B on radioresistant MCF-7 cells after exposure of cytokine-induced killer cells to sensitized targets. In addition, we demonstrated that cytokine-induced killer cell treatment sensitized breast cancer cells to chemotherapy via the downregulation of TK1, TYMS, and MDR1. These results indicate that cytokine-induced killer cell treatment in combination with radiotherapy and/or chemotherapy may induce synergistic antitumor activities and represent a novel strategy for breast cancer. |
| format | Article |
| id | doaj-art-db0d3c5e57c14cf09d0c8dddfc994cb2 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-db0d3c5e57c14cf09d0c8dddfc994cb22025-08-20T03:38:59ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317695961Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cellsQingming Guo0Danni Zhu1Xiaocui Bu2Xiaofang Wei3Changyou Li4Daiqing Gao5Xiaoqiang Wei6Xuezhen Ma7Peng Zhao8Biotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaBiotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaThe Affiliated Cardiovascular Hospital of Qingdao University Medical College, Qingdao, ChinaBiotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaBiotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaBiotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaDepartment of Gynaecology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaDepartment of Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaBiotherapy Center, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, ChinaRecurrence of breast cancer after radiotherapy may be partly explained by the presence of radioresistant cells. Thus, it would be desirable to develop an effective therapy against radioresistant cells. In this study, we demonstrated the intense antitumor activity of cytokine-induced killer cells against MCF-7 and radioresistant MCF-7 cells, as revealed by cytokine-induced killer–mediated cytotoxicity, tumor cell proliferation, and tumor invasion. Radioresistant MCF-7 cells were more susceptible to cytokine-induced killer cell killing. The stronger cytotoxicity of cytokine-induced killer cells against radioresistant MCF-7 cells was dependent on the expression of major histocompatibility complex class I polypeptide–related sequence A/B on radioresistant MCF-7 cells after exposure of cytokine-induced killer cells to sensitized targets. In addition, we demonstrated that cytokine-induced killer cell treatment sensitized breast cancer cells to chemotherapy via the downregulation of TK1, TYMS, and MDR1. These results indicate that cytokine-induced killer cell treatment in combination with radiotherapy and/or chemotherapy may induce synergistic antitumor activities and represent a novel strategy for breast cancer.https://doi.org/10.1177/1010428317695961 |
| spellingShingle | Qingming Guo Danni Zhu Xiaocui Bu Xiaofang Wei Changyou Li Daiqing Gao Xiaoqiang Wei Xuezhen Ma Peng Zhao Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells Tumor Biology |
| title | Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells |
| title_full | Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells |
| title_fullStr | Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells |
| title_full_unstemmed | Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells |
| title_short | Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells |
| title_sort | efficient killing of radioresistant breast cancer cells by cytokine induced killer cells |
| url | https://doi.org/10.1177/1010428317695961 |
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