Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats
Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) leve...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/810948 |
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| _version_ | 1832554461586784256 |
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| author | Ozlem Alici Havva Sahin Kavakli Cemile Koca Neriman Defne Altintas Murat Aydin Suleyman Alici |
| author_facet | Ozlem Alici Havva Sahin Kavakli Cemile Koca Neriman Defne Altintas Murat Aydin Suleyman Alici |
| author_sort | Ozlem Alici |
| collection | DOAJ |
| description | Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis. |
| format | Article |
| id | doaj-art-dabe28e0a9554d45b3d6e0522de3d307 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dabe28e0a9554d45b3d6e0522de3d3072025-02-03T05:51:32ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/810948810948Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in RatsOzlem Alici0Havva Sahin Kavakli1Cemile Koca2Neriman Defne Altintas3Murat Aydin4Suleyman Alici5Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, TurkeyBackground and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups. Results. Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction. Conclusion. Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis.http://dx.doi.org/10.1155/2015/810948 |
| spellingShingle | Ozlem Alici Havva Sahin Kavakli Cemile Koca Neriman Defne Altintas Murat Aydin Suleyman Alici Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats Mediators of Inflammation |
| title | Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats |
| title_full | Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats |
| title_fullStr | Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats |
| title_full_unstemmed | Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats |
| title_short | Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats |
| title_sort | value of caffeic acid phenethyl ester pretreatment in experimental sepsis model in rats |
| url | http://dx.doi.org/10.1155/2015/810948 |
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