Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis
BackgroundTumor necrosis factor blockers can suppress immune system and lead to various adverse drug reactions, including deaths. We present a rare case of dysgeusia, strawberry tongue, and psoriasis-like eruptions after simultaneous administration of adalimumab, sulfasalazine, and etoricoxib.Case d...
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Frontiers Media S.A.
2025-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1419922/full |
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| author | Binglin Cui Jing Lin Yuanchun Huang Huachen Zhu Huachen Zhu Huachen Zhu Jinbo Zou Jiesheng Qin Hui Pan Hui Pan Jian Chen |
| author_facet | Binglin Cui Jing Lin Yuanchun Huang Huachen Zhu Huachen Zhu Huachen Zhu Jinbo Zou Jiesheng Qin Hui Pan Hui Pan Jian Chen |
| author_sort | Binglin Cui |
| collection | DOAJ |
| description | BackgroundTumor necrosis factor blockers can suppress immune system and lead to various adverse drug reactions, including deaths. We present a rare case of dysgeusia, strawberry tongue, and psoriasis-like eruptions after simultaneous administration of adalimumab, sulfasalazine, and etoricoxib.Case descriptionA 36 year-old male with ankylosing spondylitis presented with progressive loss of taste for 3 months and rashes on his upper trunk for 5 days. He had been receiving adalimumab, sulfasalazine, and etoricoxib for 9 months. After self-discontinuing the medicines, the rashes gradually subsided. On examination, swollen and red strawberry tongue were noticed. Acinetobacter pittii was isolated by sputum culture. The patient refused any treatment. During follow-up, recurrent dispersed papules/macules and desquamation appeared on his upper trunk, with erythema and erosion in umbilical region. Subsequently, generalized scalp erythema, exudates, scabs, hair bundles, redness and desquamation behind ears occurred. The tongue, taste, and skin lesions resolved sequentially and steadily until complete recovery.OutcomeHe remained in remission during 4 years follow-up. The total course of disease was around 10 months.DiscussionClinicians should be cautious of the adverse drug reactions/events due to adalimumab, sulfasalazine, and etoricoxib. Rational use of medicines is advocated. |
| format | Article |
| id | doaj-art-dab73b25e1ec4bdd98772460c1da5a6d |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-dab73b25e1ec4bdd98772460c1da5a6d2025-02-03T05:11:51ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.14199221419922Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitisBinglin Cui0Jing Lin1Yuanchun Huang2Huachen Zhu3Huachen Zhu4Huachen Zhu5Jinbo Zou6Jiesheng Qin7Hui Pan8Hui Pan9Jian Chen10Department of Pediatrics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Oncology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaMicrobiology Division, Department of Clinical Microbiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaGuangdong-Hong Kong Joint Laboratory of Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, ChinaJoint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases, Joint Institute of Virology (STU/HKU), Shantou University, Shantou, Guangdong, ChinaState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, School of Public Health, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Dermatology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Otorhinolaryngology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaDepartment of Outpatient, Shantou Longhu People’s Hospital, Shantou, Guangdong, China0Clinical Research Unit, Shantou University Medical College, Shantou, Guangdong, China1Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, ChinaBackgroundTumor necrosis factor blockers can suppress immune system and lead to various adverse drug reactions, including deaths. We present a rare case of dysgeusia, strawberry tongue, and psoriasis-like eruptions after simultaneous administration of adalimumab, sulfasalazine, and etoricoxib.Case descriptionA 36 year-old male with ankylosing spondylitis presented with progressive loss of taste for 3 months and rashes on his upper trunk for 5 days. He had been receiving adalimumab, sulfasalazine, and etoricoxib for 9 months. After self-discontinuing the medicines, the rashes gradually subsided. On examination, swollen and red strawberry tongue were noticed. Acinetobacter pittii was isolated by sputum culture. The patient refused any treatment. During follow-up, recurrent dispersed papules/macules and desquamation appeared on his upper trunk, with erythema and erosion in umbilical region. Subsequently, generalized scalp erythema, exudates, scabs, hair bundles, redness and desquamation behind ears occurred. The tongue, taste, and skin lesions resolved sequentially and steadily until complete recovery.OutcomeHe remained in remission during 4 years follow-up. The total course of disease was around 10 months.DiscussionClinicians should be cautious of the adverse drug reactions/events due to adalimumab, sulfasalazine, and etoricoxib. Rational use of medicines is advocated.https://www.frontiersin.org/articles/10.3389/fmed.2025.1419922/fulldysgeusiastrawberry tonguepsoriasis-like eruptionadalimumabadverse drug reactioncase report |
| spellingShingle | Binglin Cui Jing Lin Yuanchun Huang Huachen Zhu Huachen Zhu Huachen Zhu Jinbo Zou Jiesheng Qin Hui Pan Hui Pan Jian Chen Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis Frontiers in Medicine dysgeusia strawberry tongue psoriasis-like eruption adalimumab adverse drug reaction case report |
| title | Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis |
| title_full | Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis |
| title_fullStr | Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis |
| title_full_unstemmed | Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis |
| title_short | Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis |
| title_sort | case report dysgeusia strawberry tongue and psoriatic eruptions after combination treatment with adalimumab sulfasalazine and etoricoxib for ankylosing spondylitis |
| topic | dysgeusia strawberry tongue psoriasis-like eruption adalimumab adverse drug reaction case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1419922/full |
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