Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating
Since inferior biomimetic fabrication and anti-thrombosis process always lead to the implantation failure of artificial vascular grafts, the development of bioactive platform which can promote endothelialization is fundamental in the research for blood vessel substitutes to overcome the low-efficien...
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004948 |
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| author | Shiwei Niu Fan Li Zhi Lin Bo Chen Lechun Lyu Yongliang Jiang Wanting Li Jianlin Jiao Yi Han Di Lu Lin Sun |
| author_facet | Shiwei Niu Fan Li Zhi Lin Bo Chen Lechun Lyu Yongliang Jiang Wanting Li Jianlin Jiao Yi Han Di Lu Lin Sun |
| author_sort | Shiwei Niu |
| collection | DOAJ |
| description | Since inferior biomimetic fabrication and anti-thrombosis process always lead to the implantation failure of artificial vascular grafts, the development of bioactive platform which can promote endothelialization is fundamental in the research for blood vessel substitutes to overcome the low-efficiency or hyperplasia. To solve the limitation of insufficient autologous sources of small blood vessels, this study prepared a tri-layer small diameter vascular based on citrate, followed by covalently immobilizing of specific peptides to achieve in situ cells enrichment. The natural carbohydrate of carboxymethyl chitosan is creatively used as the inner layer of tubular graft, thus exerting the anti-thrombosis effect. Moreover, the gastrodin coating was employed to alleviate the inflammation response and increase the safety of this surgically implanted vascular scaffold. The synthesis process was characterized, its biocompatibility, hierarchically cell induction capacity, anticoagulant effect and the ability to promote neovascularization were evaluated. In such way, we hope to prepare a biodegradable small-diameter artificial vascular for the clinical application. |
| format | Article |
| id | doaj-art-da70e97429d54148bc66449e05e86b41 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-da70e97429d54148bc66449e05e86b412025-01-26T05:04:21ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-01455870Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coatingShiwei Niu0Fan Li1Zhi Lin2Bo Chen3Lechun Lyu4Yongliang Jiang5Wanting Li6Jianlin Jiao7Yi Han8Di Lu9Lin Sun10Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR ChinaYunnan Key Laboratory of Stem Cell and Regenerative Medicine, College of Rehabilitation, Kunming Medical University, Kunming, 650500, PR China; Corresponding author.Department of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, PR China; Corresponding author.Since inferior biomimetic fabrication and anti-thrombosis process always lead to the implantation failure of artificial vascular grafts, the development of bioactive platform which can promote endothelialization is fundamental in the research for blood vessel substitutes to overcome the low-efficiency or hyperplasia. To solve the limitation of insufficient autologous sources of small blood vessels, this study prepared a tri-layer small diameter vascular based on citrate, followed by covalently immobilizing of specific peptides to achieve in situ cells enrichment. The natural carbohydrate of carboxymethyl chitosan is creatively used as the inner layer of tubular graft, thus exerting the anti-thrombosis effect. Moreover, the gastrodin coating was employed to alleviate the inflammation response and increase the safety of this surgically implanted vascular scaffold. The synthesis process was characterized, its biocompatibility, hierarchically cell induction capacity, anticoagulant effect and the ability to promote neovascularization were evaluated. In such way, we hope to prepare a biodegradable small-diameter artificial vascular for the clinical application.http://www.sciencedirect.com/science/article/pii/S2452199X24004948BiomimeticPeptidesHierarical cell recruitmentVascular graftGastrodin coating |
| spellingShingle | Shiwei Niu Fan Li Zhi Lin Bo Chen Lechun Lyu Yongliang Jiang Wanting Li Jianlin Jiao Yi Han Di Lu Lin Sun Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating Bioactive Materials Biomimetic Peptides Hierarical cell recruitment Vascular graft Gastrodin coating |
| title | Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating |
| title_full | Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating |
| title_fullStr | Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating |
| title_full_unstemmed | Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating |
| title_short | Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating |
| title_sort | biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating |
| topic | Biomimetic Peptides Hierarical cell recruitment Vascular graft Gastrodin coating |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004948 |
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