Synthetic Retinoid Sulfarotene Selectively Inhibits Tumor‐Repopulating Cells of Intrahepatic Cholangiocarcinoma via Disrupting Cytoskeleton by P‐Selectin/PSGL1 N‐Glycosylation Blockage

Synthetic Retinoid Sulfarotene Selectively Inhibits Tumor‐Repopulating Cells of Intrahepatic Cholangiocarcinoma via Disrupting Cytoskeleton by P‐Selectin/PSGL1 N‐Glycosylation Blockage

Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly lethal malignancy that currently lacks effective clinical treatments. Eliminating stem cell‐like cancer cells is an extremely promising but challenging strategy for treating ICC. A recently developed synthetic retinoid, sulfarotene, abrogate...

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Bibliographic Details
Main Authors: Xiaojing Du, Zhuoran Qi, Sinuo Chen, Jinlan Wu, Ye Xu, Sunkuan Hu, Zhijie Yu, Jiayun Hou, Yuan Fang, Jinglin Xia, Xin Cao
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
core fucosylation
cytoskeleton
intrahepatic cholangiocarcinoma
P‐selectin/PSGL1
synthetic retinoid
tumor‐repopulating cells
Online Access:https://doi.org/10.1002/advs.202407519
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https://doi.org/10.1002/advs.202407519

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