Mdivi-1 alleviates nicotine-induced human periodontal ligament cells injury by inhibiting mitochondrial fission and dysfunction through the JNK/Drp1 pathway

Mdivi-1 alleviates nicotine-induced human periodontal ligament cells injury by inhibiting mitochondrial fission and dysfunction through the JNK/Drp1 pathway

Background: Nicotine, a major component of tobacco, is implicated in the pathogenesis of periodontitis. However, the exact mechanisms through which nicotine exerts its harmful effects remain incompletely understood. This study investigates the impact of nicotine-induced mitochondrial fission on huma...

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Bibliographic Details
Main Authors: Leihua Cui, Meiqiao Chen, Yihong Jin, Huining Wang, Yubo Hou
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Smoking
Nicotine
Periodontitis
Human periodontal ligament cells
Apoptosis
C‑Jun N‑terminal kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324014143
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