DNA methylation patterns associated with prior tuberculosis infection in people with HIV

DNA methylation patterns associated with prior tuberculosis infection in people with HIV

Abstract Mechanisms by which prior tuberculosis (TB) increases long-term risk for cancer, cardiovascular, and neurological disorders remain unclear, particularly in people with HIV (PWH). This study investigated DNA methylation (DNAm) patterns and associated pathways in PWH with and without prior TB...

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Main Authors: Joseph Baruch Baluku, Sharon Namiiro, Daphine Kigongo Zawedde, Brenda Namanda, Hakiimu Kawalya, Irene Najjingo, Waiswa Geoffrey, Nixon Niyonzima, Naghib Bogere, Edwin Nuwagira, Joshua Rhein, Nick Jones, Christian Kraef, Megan Shaughnessy, Arohi Chauhan, Immaculate Nankya, Sayoki Mfinanga, Stanton Gerson, Bruce Kirenga
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
DNA methylation
TB
HIV
Cancer
Cardiovascular disease
Dementia
Online Access:https://doi.org/10.1038/s41598-025-15532-5
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https://doi.org/10.1038/s41598-025-15532-5

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