Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance

Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance

Abstract Yes-associated protein (YAP) activation confers resistance to chemotherapy and targeted therapy. Methionine participates in cellular processes by converting to methyl donor for the methylation of DNA, RNA and protein. However, it remains unclear whether methionine affects drug resistance by...

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Main Authors: Xia-Lu Hong, Chen-Kai Huang, Hui Qian, Chen-Hong Ding, Fang Liu, Huan-Yu Hong, Shu-Qing Liu, Si-Han Wu, Xin Zhang, Wei-Fen Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55769-8
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https://doi.org/10.1038/s41467-024-55769-8

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