Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia

Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia

Abstract Background Previous studies have found a reduction in butyrate-producing bacteria in the gut microbiota of infants with biliary atresia (BA). Butyrate is also an important inhibitor of histone deacetylase 2 (HDAC2). This study aims to explore how butyrate alleviates liver fibrosis in BA thr...

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Bibliographic Details
Main Authors: Yilin Zhao, Xiaodan Xu, Shaowen Liu, Xueting Wang, Jiayinaxi Musha, Tengfei Li, Liang Ge, Yan Sun, Shujian Zhang, Li Zhao, Jianghua Zhan
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Pediatrics
Subjects:
Biliary atresia
Fibrosis
Butyrate
HDAC2
IL-6
STAT3
Online Access:https://doi.org/10.1186/s12887-025-05635-3
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https://doi.org/10.1186/s12887-025-05635-3

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