Recombinant human thrombopoietin improves hematopoietic stem cell differentiation and T-cell immune homeostasis in patients with severe aplastic anemia by upregulating c-MPL

Recombinant human thrombopoietin improves hematopoietic stem cell differentiation and T-cell immune homeostasis in patients with severe aplastic anemia by upregulating c-MPL

BackgroundRecombinant human thrombopoietin (rhTPO) regulates platelet production by promoting megakaryocyte proliferation and has shown promising therapeutic effects in hematopoietic recovery for severe aplastic anemia (SAA). However, its potential impact on immune cells remains unclear.MethodsThis...

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Bibliographic Details
Main Authors: Ling Deng, Chenchen Liu, Yiyu Guo, Chunyan Liu, Rong Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
severe aplastic anemia
rhTPO
c-MPL
T-cell immune homeostasis
hematopoietic stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1542837/full
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