Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report
Bowen's disease (BD) is an intraepithelial squamous cell carcinoma (SCC) that commonly affects older individuals, with the vulva being a prevalent site in women. Lesions within the vagina pose a particular challenge for surgical treatment, often compromising both functional integrity and cosmes...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024005015 |
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| Summary: | Bowen's disease (BD) is an intraepithelial squamous cell carcinoma (SCC) that commonly affects older individuals, with the vulva being a prevalent site in women. Lesions within the vagina pose a particular challenge for surgical treatment, often compromising both functional integrity and cosmesis. Photodynamic therapy (PDT) is an emerging, safe, and non-invasive technique utilizing a photosensitizer and a specific light source, widely applied in the treatment of malignancies and skin diseases. We report the case of a 74-year-old woman presenting with a large, dark brown patch on the vulva, histopathologically confirmed as BD. The patient also had lesions within the vagina. Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) was administered, with an optical fiber used for targeted treatment of the vaginal lesions. Complete resolution of the lesions was observed after a single treatment. A follow-up biopsy at 7 months post-treatment revealed no residual tumor cells. The patient remains disease-free at 2 years follow-up and continues to be monitored. This case suggests that HpD-PDT is a viable treatment option for BD, and may be particularly advantageous for elderly patients with extensive or vaginally located lesions, where preserving function and cosmesis is paramount. |
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| ISSN: | 1572-1000 |