Oxidant-free cross-dehydrogenative oxyalkylation enables late-stage functionalization of drugs

Oxidant-free cross-dehydrogenative oxyalkylation enables late-stage functionalization of drugs

Late-stage functionalization is an attractive strategy that allows chemists to bypass lengthy synthetic processes, facilitating the rapid generation of drug analogs with potentially enhanced pharmacokinetic and pharmacological properties. This study describes a novel approach for cross-dehydrogenati...

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Bibliographic Details
Main Authors: Weiqiu Liang, Jiahao Li, Jianbin Li, Chengda Wu, Zhiyu Tu, Bo-Shuai Mu, Yang Xu, Longlong Song, Mengxin Xu, Xi-Yang Cui, Chao-Jun Li, Zhibo Liu
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:The Innovation
Subjects:
ionizing radiation
minisci reaction
late-stage functionalization
Online Access:http://www.sciencedirect.com/science/article/pii/S2666675825000128
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