Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery
Objective. Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation and systemic proinflammatory cytokines release. Methods. Ninety patients undergoing tangential excision surgery w...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/601083 |
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| author | Wujun Geng Wandong Hong Junlu Wang Qinxue Dai Yunchang Mo Kejian Shi Jiehao Sun Jinling Qin Mei Li Hongli Tang |
| author_facet | Wujun Geng Wandong Hong Junlu Wang Qinxue Dai Yunchang Mo Kejian Shi Jiehao Sun Jinling Qin Mei Li Hongli Tang |
| author_sort | Wujun Geng |
| collection | DOAJ |
| description | Objective. Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation and systemic proinflammatory cytokines release. Methods. Ninety patients undergoing tangential excision surgery were randomly assigned to three groups: (1) preoperative dose of 100 mg flurbiprofen axetil and a postoperative dose of 2 μg/kg sufentanil and 10 mL placebo by patient-controlled analgesia (PCA) pump, (2) preoperative dose of 100 mg flurbiprofen axetil and a postoperative dose of 2 μg/kg sufentanil and 100 mg flurbiprofen axetil by PCA pump, and (3) 10 mL placebo and a postoperative dose of 2 μg/kg sufentanil and 10 mL placebo by PCA pump. Results. Preoperative administration of flurbiprofen axetil decreased postoperative tramadol consumption and the visual analog scale at 4, 6, 12, and 24 h after surgery, which were further decreased by postoperative administration of flurbiprofen axetil. Furthermore, flurbiprofen axetil attenuated emergency agitation score and Ramsay score at 0, 5, and 10 min after extubation and reduced the TNF-α and interleukin- (IL-) 6 levels at 24 and 48 h after the operation. Conclusion. Flurbiprofen axetil enhances analgesic effects of sufentanil and attenuates emergence agitation and systemic proinflammation in patients undergoing tangential excision surgery. |
| format | Article |
| id | doaj-art-d9c4afb026844f54ba7ed8dffbb0e016 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d9c4afb026844f54ba7ed8dffbb0e0162025-02-03T01:26:05ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/601083601083Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision SurgeryWujun Geng0Wandong Hong1Junlu Wang2Qinxue Dai3Yunchang Mo4Kejian Shi5Jiehao Sun6Jinling Qin7Mei Li8Hongli Tang9Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Anesthesia, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510000, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaObjective. Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation and systemic proinflammatory cytokines release. Methods. Ninety patients undergoing tangential excision surgery were randomly assigned to three groups: (1) preoperative dose of 100 mg flurbiprofen axetil and a postoperative dose of 2 μg/kg sufentanil and 10 mL placebo by patient-controlled analgesia (PCA) pump, (2) preoperative dose of 100 mg flurbiprofen axetil and a postoperative dose of 2 μg/kg sufentanil and 100 mg flurbiprofen axetil by PCA pump, and (3) 10 mL placebo and a postoperative dose of 2 μg/kg sufentanil and 10 mL placebo by PCA pump. Results. Preoperative administration of flurbiprofen axetil decreased postoperative tramadol consumption and the visual analog scale at 4, 6, 12, and 24 h after surgery, which were further decreased by postoperative administration of flurbiprofen axetil. Furthermore, flurbiprofen axetil attenuated emergency agitation score and Ramsay score at 0, 5, and 10 min after extubation and reduced the TNF-α and interleukin- (IL-) 6 levels at 24 and 48 h after the operation. Conclusion. Flurbiprofen axetil enhances analgesic effects of sufentanil and attenuates emergence agitation and systemic proinflammation in patients undergoing tangential excision surgery.http://dx.doi.org/10.1155/2015/601083 |
| spellingShingle | Wujun Geng Wandong Hong Junlu Wang Qinxue Dai Yunchang Mo Kejian Shi Jiehao Sun Jinling Qin Mei Li Hongli Tang Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery Mediators of Inflammation |
| title | Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery |
| title_full | Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery |
| title_fullStr | Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery |
| title_full_unstemmed | Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery |
| title_short | Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery |
| title_sort | flurbiprofen axetil enhances analgesic effects of sufentanil and attenuates postoperative emergence agitation and systemic proinflammation in patients undergoing tangential excision surgery |
| url | http://dx.doi.org/10.1155/2015/601083 |
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