1,25(OH)₂D₃ inhibits ferroptosis in nucleus pulposus cells via VDR signaling to mitigate lumbar intervertebral disc degeneration

1,25(OH)₂D₃ inhibits ferroptosis in nucleus pulposus cells via VDR signaling to mitigate lumbar intervertebral disc degeneration

Abstract Lumbar intervertebral disc degeneration (LIDD) serves as a principal contributor to low back pain, a condition that poses considerable global health and socioeconomic challenges. Recent studies have emphasized the significance of ferroptosis, an iron-dependent mechanism of programmed cell d...

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Bibliographic Details
Main Authors: Qiang Li, Jing Peng, Fan Ding
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Lumbar intervertebral disc degeneration
1,25(OH)₂D₃
Ferroptosis
Nucleus pulposus cells
Vitamin D receptor
Online Access:https://doi.org/10.1038/s41598-025-92405-x
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https://doi.org/10.1038/s41598-025-92405-x

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