Wharton’s jelly-derived mesenchymal stem cells ameliorate high altitude-induced heart injury by promoting type 2 macrophage polarization via COX2-PGE2 pathway

Wharton’s jelly-derived mesenchymal stem cells ameliorate high altitude-induced heart injury by promoting type 2 macrophage polarization via COX2-PGE2 pathway

BackgroundChronic high-altitude hypobaric hypoxia leads to high-altitude heart disease and heart failure. Recent research has indicated that WJMSCs (Wharton’s jelly-derived mesenchymal stem cells, WJMSCs) can alleviate ischemic myocardial injury and improve cardiac dysfunction, and macrophage polari...

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Main Authors: Wenhong Zhang, Li Zhao, Jing Cui, Yan Zhang, Dongtao Li, Zhibo Hong, Jiamin Liu, Shan Wang, Ningkun Zhang, Yang Li, Yu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Wharton’s jelly-derived mesenchymal stem cells
high-altitude-induced heart injury
hypobaric hypoxia
macrophage polarization
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538046/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538046/full

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