Glutamatergic synaptic resilience to overexpressed human alpha-synuclein

Abstract Alpha synuclein (aSyn) is abundant in the brain and strongly implicated in Parkinson’s disease (PD), genetically and through its accumulation in neuronal pathognomonic inclusions. While mutations or increased expression of wild-type aSyn can cause familial PD, it remains unclear whether inc...

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Bibliographic Details
Main Authors: Patrícia I. Santos, Inés Hojas García-Plaza, Ali Shaib, Jeong Seop Rhee, Abed Alrahman Chouaib, Nils Brose, Silvio O. Rizzoli, James Daniel, Tiago F. Outeiro
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01085-x
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