Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation
The multifunctional role of mast cells (MCs) in the immune system is complex and has not fully been explored. MCs reside in tissues and mucous membranes such as the lung, digestive tract, and skin which are strategically located at interfaces with the external environment. These cells, therefore, wi...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2785971 |
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| author | Esmaeil Mortaz Saeede Amani Sharon Mumby Ian M. Adcock Mehrnaz Movassaghi Jelle Folkerts Johan Garssen Gert Folkerts |
| author_facet | Esmaeil Mortaz Saeede Amani Sharon Mumby Ian M. Adcock Mehrnaz Movassaghi Jelle Folkerts Johan Garssen Gert Folkerts |
| author_sort | Esmaeil Mortaz |
| collection | DOAJ |
| description | The multifunctional role of mast cells (MCs) in the immune system is complex and has not fully been explored. MCs reside in tissues and mucous membranes such as the lung, digestive tract, and skin which are strategically located at interfaces with the external environment. These cells, therefore, will encounter external stimuli and pathogens. MCs modulate both the innate and the adaptive immune response in inflammatory disorders including transplantation. MCs can have pro- and anti-inflammatory functions, thereby regulating the outcome of lung transplantation through secretion of mediators that allow interaction with other cell types, particularly innate lymphoid cells (ILC2). ILC2 cells are a unique population of hematopoietic cells that coordinate the innate immune response against a variety of threats including infection, tissue damage, and homeostatic disruption. In addition, MCs can modulate alloreactive T cell responses or assist in T regulatory (Treg) cell activity. This paper outlines the current understanding of the role of MCs in lung transplantation, with a specific focus on their interaction with ILC2 cells within the engrafted organ. |
| format | Article |
| id | doaj-art-d9842f1e2e814e81b8c27f40a56c041f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d9842f1e2e814e81b8c27f40a56c041f2025-02-03T01:03:05ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/27859712785971Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung TransplantationEsmaeil Mortaz0Saeede Amani1Sharon Mumby2Ian M. Adcock3Mehrnaz Movassaghi4Jelle Folkerts5Johan Garssen6Gert Folkerts7Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranCell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, UKCell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, UKDepartment of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, NetherlandsThe multifunctional role of mast cells (MCs) in the immune system is complex and has not fully been explored. MCs reside in tissues and mucous membranes such as the lung, digestive tract, and skin which are strategically located at interfaces with the external environment. These cells, therefore, will encounter external stimuli and pathogens. MCs modulate both the innate and the adaptive immune response in inflammatory disorders including transplantation. MCs can have pro- and anti-inflammatory functions, thereby regulating the outcome of lung transplantation through secretion of mediators that allow interaction with other cell types, particularly innate lymphoid cells (ILC2). ILC2 cells are a unique population of hematopoietic cells that coordinate the innate immune response against a variety of threats including infection, tissue damage, and homeostatic disruption. In addition, MCs can modulate alloreactive T cell responses or assist in T regulatory (Treg) cell activity. This paper outlines the current understanding of the role of MCs in lung transplantation, with a specific focus on their interaction with ILC2 cells within the engrafted organ.http://dx.doi.org/10.1155/2018/2785971 |
| spellingShingle | Esmaeil Mortaz Saeede Amani Sharon Mumby Ian M. Adcock Mehrnaz Movassaghi Jelle Folkerts Johan Garssen Gert Folkerts Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation Journal of Immunology Research |
| title | Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation |
| title_full | Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation |
| title_fullStr | Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation |
| title_full_unstemmed | Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation |
| title_short | Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation |
| title_sort | role of mast cells and type 2 innate lymphoid ilc2 cells in lung transplantation |
| url | http://dx.doi.org/10.1155/2018/2785971 |
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