Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study

Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study

Abstract In this study, new cinnamic acid linked to triazole acetamide derivatives was synthesized and evaluated for anti-Alzheimer and anti-melanogenesis activities. The structural elucidation of all analogs was performed using different analytical techniques, including 1H-NMR, 13C-NMR, mass spectr...

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Main Authors: Amir Shervin Shokouhi Asl, Mohammad Hosein Sayahi, Mohammad Hashem Hashempur, Cambyz Irajie, Amir Hossein Alaeddini, Seyedeh Niloufar Ghafouri, Milad Noori, Navid Dastyafteh, Javad Mottaghipisheh, Mehdi Asadi, Bagher Larijani, Mohammad Mahdavi, Aida Iraji
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Acetylcholinesterase
Alzheimer’s disease
Butyrylcholinesterase
Tyrosinase
Kinetic
Cinnamic acid
Online Access:https://doi.org/10.1038/s41598-024-83020-3
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https://doi.org/10.1038/s41598-024-83020-3

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