Circulating Interferon-Gamma Levels Are Associated with Low Body Weight in Newly Diagnosed Kenyan Non-Substance Using Tuberculosis Individuals
Although interferon-gamma, interleukin-10, and adiponectin are key immunopathogenesis mediators of tuberculosis, their association with clinical manifestations of early stage disease is inconclusive. We determined interferon-gamma, interleukin-10, and adiponectin levels in clinically and phenotypica...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/9415364 |
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| Summary: | Although interferon-gamma, interleukin-10, and adiponectin are key immunopathogenesis mediators of tuberculosis, their association with clinical manifestations of early stage disease is inconclusive. We determined interferon-gamma, interleukin-10, and adiponectin levels in clinically and phenotypically well-characterised non-substance using new pulmonary tuberculosis patients (n=13) and controls (n=14) from Kenya. Interferon-gamma levels (P<0.0001) and interferon-gamma to interleukin-10 (P<0.001) and interferon-gamma to adiponectin (P=0.027) ratios were elevated in tuberculosis cases. Correlation analyses in tuberculosis cases showed associations of interferon-gamma levels with body weight (ρ=-0.849; P<0.0001), body mass index (ρ=0.664; P=0.013), hip girth (ρ=-0.579; P=0.038), and plateletcrit (ρ=0.605; P=0.028); interferon-gamma to interleukin-10 ratio with diastolic pressure (ρ=-0.729; P=0.005); and interferon-gamma to adiponectin ratio with body weight (ρ=-0.560; P=0.047), body mass index (ρ=-0.604; P=0.029), and plateletcrit (ρ=0.793; P=0.001). Taken together, our results suggest mild-inflammation in early stage infection characterised by upregulation of circulating interferon-gamma production in newly infected TB patients. |
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| ISSN: | 1687-708X 1687-7098 |