Metabotype identification via fasting and postprandial metabolomics and its association with type 2 diabetes incidence

Metabotype identification via fasting and postprandial metabolomics and its association with type 2 diabetes incidence

Abstract Background Metabotypes represent distinct metabolic profiles that groups of individuals share, facilitating disease risk stratification. We aimed to apply metabolomics to identify metabotypes in different prandial states and examine its associations with type 2 diabetes mellitus (T2DM) risk...

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Main Authors: Keyong Deng, David A. Hughes, Renée de Mutsert, Astrid van Hylckama Vlieg, Saskia le Cessie, Frits R. Rosendaal, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Nicholas J. Timpson, Ruifang Li-Gao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cardiovascular Diabetology
Subjects:
Metabolomics
Type 2 diabetes mellitus
Metabotype
Unsupervised clustering analysis
Postprandial
Online Access:https://doi.org/10.1186/s12933-025-02821-6
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https://doi.org/10.1186/s12933-025-02821-6

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