Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients
Objective. Health comorbidities, particularly cardiovascular risk factors, are well known to pose risks for cognitive decline in older adults. To date, little attention has focused on the impact of these comorbidities on Parkinson’s disease (PD). This study examined the prevalence and contribution o...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2014/507529 |
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| _version_ | 1832561250153791488 |
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| author | Jacob D. Jones Charles Jacobson Martina Murphy Catherine Price Michael S. Okun Dawn Bowers |
| author_facet | Jacob D. Jones Charles Jacobson Martina Murphy Catherine Price Michael S. Okun Dawn Bowers |
| author_sort | Jacob D. Jones |
| collection | DOAJ |
| description | Objective. Health comorbidities, particularly cardiovascular risk factors, are well known to pose risks for cognitive decline in older adults. To date, little attention has focused on the impact of these comorbidities on Parkinson’s disease (PD). This study examined the prevalence and contribution of comorbidities on cognitive status in PD patients, above and beyond the effects of disease severity. Methods. A cross sectional design was used, including neuropsychological data on 341 PD patients without severe cognitive decline. Comorbidity data were collected via medical chart review. Data were analyzed using a series of multiple hierarchical regressions, controlling for PD-related disease variables. Results. Overall sample characteristics are 69% male, disease duration 9.7 years, Unified Parkinson’s Disease Rating Scale 26.4, and age 64.7 years. Hypercholesterolemia (41.6%), hypertension (38.1%), and hypotension (30.2%) were the most reported comorbidities. The presence of hypertension significantly contributed to domains of executive function and verbal memory. The cooccurrence of orthostatic hypotension moderated the relationship between hypertension and executive function. Conclusions. This study on a large cohort of PD patients provides evidence for a detrimental influence of health comorbidities, particularly hypertension, on cognitive domains that have traditionally been conceptualized as being frontally and/or temporally mediated. |
| format | Article |
| id | doaj-art-d90a9ec16aa948749f062fbf71b59473 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-d90a9ec16aa948749f062fbf71b594732025-02-03T01:25:35ZengWileyParkinson's Disease2090-80832042-00802014-01-01201410.1155/2014/507529507529Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease PatientsJacob D. Jones0Charles Jacobson1Martina Murphy2Catherine Price3Michael S. Okun4Dawn Bowers5Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, 101 South Newell Drive, Gainesville, FL 32601, USACenter for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, 3450 Hull Road Gainesville, FL 32607, USADepartment of Internal Medicine, McKnight Brain Institute, University of Florida, P.O. Box 100277, Gainesville, FL 32610-0277, USADepartment of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, 101 South Newell Drive, Gainesville, FL 32601, USACenter for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, 3450 Hull Road Gainesville, FL 32607, USADepartment of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, 101 South Newell Drive, Gainesville, FL 32601, USAObjective. Health comorbidities, particularly cardiovascular risk factors, are well known to pose risks for cognitive decline in older adults. To date, little attention has focused on the impact of these comorbidities on Parkinson’s disease (PD). This study examined the prevalence and contribution of comorbidities on cognitive status in PD patients, above and beyond the effects of disease severity. Methods. A cross sectional design was used, including neuropsychological data on 341 PD patients without severe cognitive decline. Comorbidity data were collected via medical chart review. Data were analyzed using a series of multiple hierarchical regressions, controlling for PD-related disease variables. Results. Overall sample characteristics are 69% male, disease duration 9.7 years, Unified Parkinson’s Disease Rating Scale 26.4, and age 64.7 years. Hypercholesterolemia (41.6%), hypertension (38.1%), and hypotension (30.2%) were the most reported comorbidities. The presence of hypertension significantly contributed to domains of executive function and verbal memory. The cooccurrence of orthostatic hypotension moderated the relationship between hypertension and executive function. Conclusions. This study on a large cohort of PD patients provides evidence for a detrimental influence of health comorbidities, particularly hypertension, on cognitive domains that have traditionally been conceptualized as being frontally and/or temporally mediated.http://dx.doi.org/10.1155/2014/507529 |
| spellingShingle | Jacob D. Jones Charles Jacobson Martina Murphy Catherine Price Michael S. Okun Dawn Bowers Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients Parkinson's Disease |
| title | Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients |
| title_full | Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients |
| title_fullStr | Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients |
| title_full_unstemmed | Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients |
| title_short | Influence of Hypertension on Neurocognitive Domains in Nondemented Parkinson’s Disease Patients |
| title_sort | influence of hypertension on neurocognitive domains in nondemented parkinson s disease patients |
| url | http://dx.doi.org/10.1155/2014/507529 |
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