“Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia
Acquired amegakaryocytic thrombocytopenia (AAT) is a rare hematological disorder causing severe thrombocytopenia and bleeding. Previous in vitro studies postulated both cell-mediated suppression of megakaryocytopoiesis in early megakaryocytic progenitor cells and humoral-mediated suppression by anti...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/806541 |
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| author | Gabrielle Elena Brown Hani M. Babiker Carlos L. Cantu Andrew M. Yeager Ravitharan Krishnadasan |
| author_facet | Gabrielle Elena Brown Hani M. Babiker Carlos L. Cantu Andrew M. Yeager Ravitharan Krishnadasan |
| author_sort | Gabrielle Elena Brown |
| collection | DOAJ |
| description | Acquired amegakaryocytic thrombocytopenia (AAT) is a rare hematological disorder causing severe thrombocytopenia and bleeding. Previous in vitro studies postulated both cell-mediated suppression of megakaryocytopoiesis in early megakaryocytic progenitor cells and humoral-mediated suppression by anti-thrombopoietin antibodies as possible etiologies of AAT. Patients with AAT usually present with severe bleeding and thrombocytopenia that is unresponsive to steroids and intravenous immunoglobulin (IVIG). Although standard guidelines have not been established for management of AAT, a few case reports have indicated a response to immunosuppressive treatment. The prompt recognition of this disease entity is essential in view of the substantial risk of morbidity and mortality from excessive bleeding. We report a case of AAT successfully treated with equine antithymocyte globulin (ATG) and cyclosporine (CSP). |
| format | Article |
| id | doaj-art-d8d25ccfcfa844ebbf7d73158e8d9ddb |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d8d25ccfcfa844ebbf7d73158e8d9ddb2025-02-03T05:51:57ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/806541806541“Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic ThrombocytopeniaGabrielle Elena Brown0Hani M. Babiker1Carlos L. Cantu2Andrew M. Yeager3Ravitharan Krishnadasan4University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USADivision of Hematology-Oncology, Department of Medicine, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USADepartment of Pathology, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USADivision of Hematology-Oncology, Department of Medicine, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USADivision of Hematology-Oncology, Department of Medicine, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USAAcquired amegakaryocytic thrombocytopenia (AAT) is a rare hematological disorder causing severe thrombocytopenia and bleeding. Previous in vitro studies postulated both cell-mediated suppression of megakaryocytopoiesis in early megakaryocytic progenitor cells and humoral-mediated suppression by anti-thrombopoietin antibodies as possible etiologies of AAT. Patients with AAT usually present with severe bleeding and thrombocytopenia that is unresponsive to steroids and intravenous immunoglobulin (IVIG). Although standard guidelines have not been established for management of AAT, a few case reports have indicated a response to immunosuppressive treatment. The prompt recognition of this disease entity is essential in view of the substantial risk of morbidity and mortality from excessive bleeding. We report a case of AAT successfully treated with equine antithymocyte globulin (ATG) and cyclosporine (CSP).http://dx.doi.org/10.1155/2014/806541 |
| spellingShingle | Gabrielle Elena Brown Hani M. Babiker Carlos L. Cantu Andrew M. Yeager Ravitharan Krishnadasan “Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia Case Reports in Hematology |
| title | “Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia |
| title_full | “Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia |
| title_fullStr | “Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia |
| title_full_unstemmed | “Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia |
| title_short | “Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia |
| title_sort | almost bleeding to death the conundrum of acquired amegakaryocytic thrombocytopenia |
| url | http://dx.doi.org/10.1155/2014/806541 |
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