Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice
Herpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the trigeminal gangl...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/435140 |
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| _version_ | 1832567970579087360 |
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| author | Xiao-Tang Yin Tammie L. Keadle Jessicah Hard John Herndon Chloe A. Potter Chelsea R. Del Rosso Thomas A. Ferguson Patrick M. Stuart |
| author_facet | Xiao-Tang Yin Tammie L. Keadle Jessicah Hard John Herndon Chloe A. Potter Chelsea R. Del Rosso Thomas A. Ferguson Patrick M. Stuart |
| author_sort | Xiao-Tang Yin |
| collection | DOAJ |
| description | Herpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the trigeminal ganglia. One of the key factors that limit inflammation of the cornea is the expression of Fas ligand (FasL). We demonstrate that infection of the cornea with HSV-1 results in increased functional expression of FasL and that mice expressing mutations in Fas (lpr) and FasL (gld) display increased recurrent HSK following reactivation compared to wild-type mice. Furthermore, both gld and lpr mice took longer to clear their corneas of infectious virus and the reactivation rate for these strains was significantly greater than that seen with wild-type mice. Collectively, these findings indicate that the interaction of Fas with FasL in the cornea restricts the development of recurrent HSK. |
| format | Article |
| id | doaj-art-d8d1c5ec4e1e4a9a9a6acaf678020e32 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d8d1c5ec4e1e4a9a9a6acaf678020e322025-02-03T01:00:09ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/435140435140Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in MiceXiao-Tang Yin0Tammie L. Keadle1Jessicah Hard2John Herndon3Chloe A. Potter4Chelsea R. Del Rosso5Thomas A. Ferguson6Patrick M. Stuart7Department of Ophthalmology, Saint Louis University School of Medicine, St. Louis, MO 63104, USADepartment of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Ophthalmology, Saint Louis University School of Medicine, St. Louis, MO 63104, USADepartment of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Ophthalmology, Saint Louis University School of Medicine, St. Louis, MO 63104, USADepartment of Ophthalmology, Saint Louis University School of Medicine, St. Louis, MO 63104, USADepartment of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Ophthalmology, Saint Louis University School of Medicine, St. Louis, MO 63104, USAHerpes simplex virus-1 (HSV-1) infection of the cornea leads to a potentially blinding condition termed herpetic stromal keratitis (HSK). Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the trigeminal ganglia. One of the key factors that limit inflammation of the cornea is the expression of Fas ligand (FasL). We demonstrate that infection of the cornea with HSV-1 results in increased functional expression of FasL and that mice expressing mutations in Fas (lpr) and FasL (gld) display increased recurrent HSK following reactivation compared to wild-type mice. Furthermore, both gld and lpr mice took longer to clear their corneas of infectious virus and the reactivation rate for these strains was significantly greater than that seen with wild-type mice. Collectively, these findings indicate that the interaction of Fas with FasL in the cornea restricts the development of recurrent HSK.http://dx.doi.org/10.1155/2015/435140 |
| spellingShingle | Xiao-Tang Yin Tammie L. Keadle Jessicah Hard John Herndon Chloe A. Potter Chelsea R. Del Rosso Thomas A. Ferguson Patrick M. Stuart Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice Journal of Immunology Research |
| title | Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice |
| title_full | Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice |
| title_fullStr | Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice |
| title_full_unstemmed | Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice |
| title_short | Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice |
| title_sort | impaired fas fas ligand interactions result in greater recurrent herpetic stromal keratitis in mice |
| url | http://dx.doi.org/10.1155/2015/435140 |
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