Effects and mechanisms of long-acting glucagon-like peptide-1 receptor agonist semaglutide on microglia phenotypic transformation and neuroinflammation after cerebral ischemia/reperfusion in rats

Effects and mechanisms of long-acting glucagon-like peptide-1 receptor agonist semaglutide on microglia phenotypic transformation and neuroinflammation after cerebral ischemia/reperfusion in rats

BACKGROUND: The optimal method for addressing cerebral ischemic stroke involves promptly restoring blood supply. However, cerebral ischemia-reperfusion injury (CIRI) is an unavoidable consequence of this event. Neuroinflammation is deemed the primary mechanism of CIRI, with various activation phenot...

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Main Authors: Rulin Mi, Huifeng Cheng, Rui Chen, Bo Bai, An Li, Fankai Gao, Guofang Xue
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Brain Circulation
Subjects:
cerebral ischemia-reperfusion
glucagon-like peptide-1
m1/m2 microglia
neuroinflammation
nuclear factor kappa-light-chain-enhancer of activated b-cell signaling pathway
Online Access:https://journals.lww.com/10.4103/bc.bc_38_24
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https://journals.lww.com/10.4103/bc.bc_38_24

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