KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients

KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients

Abstract Background Polycystic ovary syndrome (PCOS) is one of the main cause of female infertility worldwide, however the aetiology of PCOS remains elusive. In our previous microarray analysis of granulosa cells (GCs), Lysine Acetyltransferase 2B (KAT2B) was significantly highly expressed in GCs of...

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Main Authors: Ao Wang, Xiao-Fei Zhang, Cong-Jian Luo, Yu-Dong Liu, Pei-Ru Chen, An-Lan Wang, Jun Zhang, Song-Yu Huang, Xin-Yi Huang, Shi-Ling Chen, Xing-Yu Zhou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Polycystic ovary syndrome
Granulosa cells
Lysine acetyltransferase 2B
Histone acetylation
Estradiol synthesis
Online Access:https://doi.org/10.1186/s12967-025-06848-x
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https://doi.org/10.1186/s12967-025-06848-x

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