The effect of the use of omeprazole versus famotidine on the kidney transplant function: a randomized controlled study

Abstract Tacrolimus is metabolized in the liver with the participation of cytochrome P450 isoforms 3A4 and 3A5 (CYP3A4, CYP3A5). Omeprazole, unlike famotidine, is a substrate and inhibitor of CYP2C19, CYP3A4, CYP3A5 enzymes. The aim of the study is to compare the effect of omeprazole and famotidine...

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Bibliographic Details
Main Authors: Miłosz Miedziaszczyk, Marek Karczewski, Ilona Idasiak-Piechocka
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-85534-w
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