YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli

YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli

Abstract Antimicrobial resistance is one of the major health threats of the modern world. Thus, new structural classes of antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids represent one such new compound class that inhibit the well-established target bacteri...

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Main Authors: Timo Risch, Dominik Kolling, Dietrich Mostert, Tim Seedorf, Dominik Heimann, Daniel Kohnhäuser, Felix Deschner, Franziska Fries, Danny Solga, Jil-Sophie Hilgers, Jan Dastbaz, Stefano Mancini, Anna K. H. Hirsch, Mark Brönstrup, Andreas Kirschning, Stephan A. Sieber, Jennifer Herrmann, Rolf Müller
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Antimicrobials and Resistance
Online Access:https://doi.org/10.1038/s44259-024-00050-7
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https://doi.org/10.1038/s44259-024-00050-7

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