Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats
IntroductionDietary interventions such as caloric restriction (CR) exert positive effects on brain health. Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic known to promote brain health. Direct comparison between the effec...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1440373/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557407164694528 |
|---|---|
| author | Judith R. A. van Rooij Judith R. A. van Rooij Monica van den Berg Monica van den Berg Tamara Vasilkovska Johan Van Audekerke Johan Van Audekerke Lauren Kosten Daniele Bertoglio Daniele Bertoglio Mohit H. Adhikari Mohit H. Adhikari Marleen Verhoye Marleen Verhoye |
| author_facet | Judith R. A. van Rooij Judith R. A. van Rooij Monica van den Berg Monica van den Berg Tamara Vasilkovska Johan Van Audekerke Johan Van Audekerke Lauren Kosten Daniele Bertoglio Daniele Bertoglio Mohit H. Adhikari Mohit H. Adhikari Marleen Verhoye Marleen Verhoye |
| author_sort | Judith R. A. van Rooij |
| collection | DOAJ |
| description | IntroductionDietary interventions such as caloric restriction (CR) exert positive effects on brain health. Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic known to promote brain health. Direct comparison between the effects of Rsv and CR on brain health is lacking, with limited knowledge on their sex-specific effects. Therefore, we aimed to compare and unravel the sex-specific impact of these dietary interventions on spontaneous brain activity.MethodsHere, we used resting-state fMRI to investigate functional connectivity (FC) changes in five prominent resting-state brain networks (RSNs) in healthy 4 month old male and female F344 rats supplemented to either 40% CR or daily Rsv supplementation (10 mg/kg, oral) for the duration of 1 month.ResultsOur results demonstrated a decreased body weight (BW) in CR rats, as well as an increase in body weight in male Rsv supplemented rats, compared to female Rsv supplemented rats, whereas this difference between sexes was not observed in the control or CR groups. Furthermore, we found that both CR or Rsv supplementation induce a female-specific decrease of FC between the subcortical network and hippocampal network, and between the subcortical network and lateral cortical network. Moreover, Rsv supplementation lowered FC within the hippocampal network and between the hippocampal and the default mode like network, the lateral cortical network and the sensory network—an effect not observed for the CR rats.DiscussionOur findings reveal that both CR and Rsv induce a similar female-specific decrease of FC in RSNs associated with memory and emotion, all the while CR and Rsv induce dissimilar changes in body weight and other within- and between-RSN FC measures. Altogether, this study provides insight into the effects and comparability of short-term CR and Rsv supplementation on brain connectivity within- and between-RSNs in both male and female F344 rats, providing a FC reference for future research of dietary effects. |
| format | Article |
| id | doaj-art-d80f534b315645a7b21b5989798bb69a |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-d80f534b315645a7b21b5989798bb69a2025-02-03T05:11:52ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.14403731440373Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female ratsJudith R. A. van Rooij0Judith R. A. van Rooij1Monica van den Berg2Monica van den Berg3Tamara Vasilkovska4Johan Van Audekerke5Johan Van Audekerke6Lauren Kosten7Daniele Bertoglio8Daniele Bertoglio9Mohit H. Adhikari10Mohit H. Adhikari11Marleen Verhoye12Marleen Verhoye13Bio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumμNEURO Research Centre of Excellence, University of Antwerp, Antwerp, BelgiumBio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumμNEURO Research Centre of Excellence, University of Antwerp, Antwerp, BelgiumBio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumBio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumμNEURO Research Centre of Excellence, University of Antwerp, Antwerp, BelgiumBio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumBio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumμNEURO Research Centre of Excellence, University of Antwerp, Antwerp, BelgiumBio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumμNEURO Research Centre of Excellence, University of Antwerp, Antwerp, BelgiumBio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, BelgiumμNEURO Research Centre of Excellence, University of Antwerp, Antwerp, BelgiumIntroductionDietary interventions such as caloric restriction (CR) exert positive effects on brain health. Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic known to promote brain health. Direct comparison between the effects of Rsv and CR on brain health is lacking, with limited knowledge on their sex-specific effects. Therefore, we aimed to compare and unravel the sex-specific impact of these dietary interventions on spontaneous brain activity.MethodsHere, we used resting-state fMRI to investigate functional connectivity (FC) changes in five prominent resting-state brain networks (RSNs) in healthy 4 month old male and female F344 rats supplemented to either 40% CR or daily Rsv supplementation (10 mg/kg, oral) for the duration of 1 month.ResultsOur results demonstrated a decreased body weight (BW) in CR rats, as well as an increase in body weight in male Rsv supplemented rats, compared to female Rsv supplemented rats, whereas this difference between sexes was not observed in the control or CR groups. Furthermore, we found that both CR or Rsv supplementation induce a female-specific decrease of FC between the subcortical network and hippocampal network, and between the subcortical network and lateral cortical network. Moreover, Rsv supplementation lowered FC within the hippocampal network and between the hippocampal and the default mode like network, the lateral cortical network and the sensory network—an effect not observed for the CR rats.DiscussionOur findings reveal that both CR and Rsv induce a similar female-specific decrease of FC in RSNs associated with memory and emotion, all the while CR and Rsv induce dissimilar changes in body weight and other within- and between-RSN FC measures. Altogether, this study provides insight into the effects and comparability of short-term CR and Rsv supplementation on brain connectivity within- and between-RSNs in both male and female F344 rats, providing a FC reference for future research of dietary effects.https://www.frontiersin.org/articles/10.3389/fnut.2025.1440373/fullcaloric restrictionresveratrolresting-state functional MRIresting-state networksfunctional connectivity |
| spellingShingle | Judith R. A. van Rooij Judith R. A. van Rooij Monica van den Berg Monica van den Berg Tamara Vasilkovska Johan Van Audekerke Johan Van Audekerke Lauren Kosten Daniele Bertoglio Daniele Bertoglio Mohit H. Adhikari Mohit H. Adhikari Marleen Verhoye Marleen Verhoye Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats Frontiers in Nutrition caloric restriction resveratrol resting-state functional MRI resting-state networks functional connectivity |
| title | Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats |
| title_full | Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats |
| title_fullStr | Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats |
| title_full_unstemmed | Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats |
| title_short | Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats |
| title_sort | short term caloric restriction or resveratrol supplementation alters large scale brain network connectivity in male and female rats |
| topic | caloric restriction resveratrol resting-state functional MRI resting-state networks functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1440373/full |
| work_keys_str_mv | AT judithravanrooij shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT judithravanrooij shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT monicavandenberg shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT monicavandenberg shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT tamaravasilkovska shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT johanvanaudekerke shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT johanvanaudekerke shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT laurenkosten shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT danielebertoglio shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT danielebertoglio shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT mohithadhikari shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT mohithadhikari shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT marleenverhoye shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats AT marleenverhoye shorttermcaloricrestrictionorresveratrolsupplementationalterslargescalebrainnetworkconnectivityinmaleandfemalerats |