Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression
The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through its F-box domain. Skp2 protein levels are r...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.89 |
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| _version_ | 1832550381204275200 |
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| author | Chia-Hsin Chan Szu-Wei Lee Jing Wang Hui-Kuan Lin |
| author_facet | Chia-Hsin Chan Szu-Wei Lee Jing Wang Hui-Kuan Lin |
| author_sort | Chia-Hsin Chan |
| collection | DOAJ |
| description | The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through its F-box domain. Skp2 protein levels are regulated during the cell cycle, and recent studies reveal that Skp2 stability, subcellular localization, and activity are regulated by its phosphorylation. Overexpression of Skp2 is associated with a variety of human cancers, indicating that Skp2 may contribute to the development of human cancers. The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers. |
| format | Article |
| id | doaj-art-d80c660b76f847e7bb815f2067f07962 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d80c660b76f847e7bb815f2067f079622025-02-03T06:06:57ZengWileyThe Scientific World Journal1537-744X2010-01-01101001101510.1100/tsw.2010.89Regulation of Skp2 Expression and Activity and Its Role in Cancer ProgressionChia-Hsin Chan0Szu-Wei Lee1Jing Wang2Hui-Kuan Lin3Department of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USADepartment of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USADepartment of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USADepartment of Molecular and Cellular Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USAThe regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through its F-box domain. Skp2 protein levels are regulated during the cell cycle, and recent studies reveal that Skp2 stability, subcellular localization, and activity are regulated by its phosphorylation. Overexpression of Skp2 is associated with a variety of human cancers, indicating that Skp2 may contribute to the development of human cancers. The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers.http://dx.doi.org/10.1100/tsw.2010.89 |
| spellingShingle | Chia-Hsin Chan Szu-Wei Lee Jing Wang Hui-Kuan Lin Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression The Scientific World Journal |
| title | Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression |
| title_full | Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression |
| title_fullStr | Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression |
| title_full_unstemmed | Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression |
| title_short | Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression |
| title_sort | regulation of skp2 expression and activity and its role in cancer progression |
| url | http://dx.doi.org/10.1100/tsw.2010.89 |
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