Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate

Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45% of MMF recipients. The active form of the...

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Bibliographic Details
Main Authors: Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina B. Borlandelli, Marissa M. Bivins, Natalie K. Barker, Alicia A. Sorgen, Angie L. Mordant, Rebecca L. Johnson, Aadra P. Bhatt, Anthony A. Fodor, Laura E. Herring, Hermen Overkleeft, John R. Lee, Matthew. R. Redinbo
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Multi-Omics
Metagenomics
Proteomics
Metaproteomics
Microbiome
Glycoside Hyrolase
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2107289
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https://www.tandfonline.com/doi/10.1080/19490976.2022.2107289

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