Synthesis, Characterization, and Antimicrobial Properties of a New Ligand and Its Pd(II), Ru(II), Fe(II), Co(II) Complexes
Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Düzce University
2018-04-01
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| Series: | Düzce Üniversitesi Bilim ve Teknoloji Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/pub/dubited/issue/35735/356718?publisher=duzce |
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| Summary: | Schiff bases and their complexes are versatile
compounds synthesized from the condensation of an amino compound with carbonyl
compounds and widely used for industrial purposes and also exhibit a broad
range of biological activities including antifungal, antibacterial,
antimalarial, antiproliferative, antiviral, and antipyretic properties. In this
study, the complexes of (E)-2-(3,5-di-tert-butyl-2-hydroxybenzylideneamino)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile
(L) with Co(II), Fe(II), Pd(II) and Ru(II) were successfully prepared.
Structures of Schiff base and its metal complexes obtained were confirmed by FT-IR, 1H-NMR, 13C-NMR,
UV–vis, magnetic
susceptibility, mass spectroscopy and elemental analysis. The synthesized Schiff base
and its metal complexes were
tested for antimicrobial activity against Enterobacter
aerogenes, Bacillus subtilis, Staphylococcus aureus, Bacillus megaterium, Pseudomonas aeroginosa, Klebsiella
pneumoniae, Escherichia coli, Candida albicans, Yarrowia lipolytica and Saccharomyces
cereviciae. When the
antimicrobial activities of the compounds were examined, it was observed that
the lowest activity was exhibited by the ligand, and the highest activity was
exhibited by the Co(II) and Pd(II) complexes. None of our compounds were been
found to exhibit antifungal activity. |
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| ISSN: | 2148-2446 |