Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growin...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6696894 |
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| _version_ | 1832547115138547712 |
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| author | Bei Yin Qingge Ma Chenghao Song Lingyi Zhao Fanyuan Yu Chenglin Wang Yu Shi Ling Ye |
| author_facet | Bei Yin Qingge Ma Chenghao Song Lingyi Zhao Fanyuan Yu Chenglin Wang Yu Shi Ling Ye |
| author_sort | Bei Yin |
| collection | DOAJ |
| description | The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatment of bone defects. Exosomes can transfer various cargoes, and noncoding RNAs are the most widely studied cargo through which exosomes exert their ability of osteoinduction. Here, we review the research status of the exosome-derived noncoding RNAs in bone regeneration, the potential application of exosomes, and the existing challenges. |
| format | Article |
| id | doaj-art-d7b4d3a3a4da4c9ca51607f2b8b24682 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d7b4d3a3a4da4c9ca51607f2b8b246822025-02-03T06:46:01ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66968946696894Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone RegenerationBei Yin0Qingge Ma1Chenghao Song2Lingyi Zhao3Fanyuan Yu4Chenglin Wang5Yu Shi6Ling Ye7State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaThe reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatment of bone defects. Exosomes can transfer various cargoes, and noncoding RNAs are the most widely studied cargo through which exosomes exert their ability of osteoinduction. Here, we review the research status of the exosome-derived noncoding RNAs in bone regeneration, the potential application of exosomes, and the existing challenges.http://dx.doi.org/10.1155/2021/6696894 |
| spellingShingle | Bei Yin Qingge Ma Chenghao Song Lingyi Zhao Fanyuan Yu Chenglin Wang Yu Shi Ling Ye Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration Stem Cells International |
| title | Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration |
| title_full | Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration |
| title_fullStr | Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration |
| title_full_unstemmed | Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration |
| title_short | Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration |
| title_sort | exosome derived noncoding rnas as a promising treatment of bone regeneration |
| url | http://dx.doi.org/10.1155/2021/6696894 |
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