Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesis

Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesis

Abstract Doxorubicin (DOX) is a key chemotherapeutic agent but is also a leading cause of DOX-induced cardiotoxicity (DIC), limiting its clinical use. Akkermansia muciniphila (A. muciniphila), known for its benefits as a probiotic in treating metabolic syndrome, has uncertain effects in the context...

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Main Authors: Hui Lin, Xian Shao, Haodi Gu, Xinrou Yu, Lingyan He, Jiedong Zhou, Zuoquan Zhong, Shitian Guo, Dan Li, Fei Chen, Yongfei Song, Lili Xu, Ping Wang, Liping Meng, Jufang Chi, Jiangfang Lian
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00712-y
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https://doi.org/10.1038/s41522-025-00712-y

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