Small T Oncoprotein of Merkel Cell Polyomavirus Attenuates Cisplatin-Induced Apoptosis and Enhances E1, E6/E7, MMP-1, and Ki-67 Expression in HeLa Cervical Cancer Cells

Small T Oncoprotein of Merkel Cell Polyomavirus Attenuates Cisplatin-Induced Apoptosis and Enhances E1, E6/E7, MMP-1, and Ki-67 Expression in HeLa Cervical Cancer Cells

Purpose: Cervical cancer (CxCa) is primarily caused by high-risk human papillomaviruses (hrHPV), which disrupt p53 and pRb regulation, leading to uncontrolled growth and progression. Co-infection with polyomaviruses like MCPyV in some HPV-positive cases suggests a potential combined effect on tumor...

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Bibliographic Details
Main Authors: Fatemeh Pakdel, Seyed Masoud Hosseini, Neda Soleimani, Ali Farhadi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2025-04-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
cervical cancer
cisplatin
stag
mcpyv
hpv-18
hela
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-15-194.pdf
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