Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors. The decision to form an aggregate is largely mad...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/736905 |
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| _version_ | 1832566644252082176 |
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| author | Trond Lamark Terje Johansen |
| author_facet | Trond Lamark Terje Johansen |
| author_sort | Trond Lamark |
| collection | DOAJ |
| description | Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors. The decision to form an aggregate is largely made by chaperones and chaperone-assisted proteins. Proteins that are damaged beyond repair are degraded either by the proteasome or by the lysosome via autophagy. The aggregates can be degraded by the proteasome and by chaperone-mediated autophagy only after dissolution into soluble single peptide species. Hence, protein aggregates as such are degraded by macroautophagy. The selective degradation of protein aggregates by macroautophagy is called aggrephagy. Here we review the processes of aggregate formation, recognition, transport, and sequestration into autophagosomes by autophagy receptors and the role of aggrephagy in different protein aggregation diseases. |
| format | Article |
| id | doaj-art-d77c31ca21214024ba932f35ff95f74d |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-d77c31ca21214024ba932f35ff95f74d2025-02-03T01:03:43ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/736905736905Aggrephagy: Selective Disposal of Protein Aggregates by MacroautophagyTrond Lamark0Terje Johansen1Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, NorwayMolecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, NorwayProtein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors. The decision to form an aggregate is largely made by chaperones and chaperone-assisted proteins. Proteins that are damaged beyond repair are degraded either by the proteasome or by the lysosome via autophagy. The aggregates can be degraded by the proteasome and by chaperone-mediated autophagy only after dissolution into soluble single peptide species. Hence, protein aggregates as such are degraded by macroautophagy. The selective degradation of protein aggregates by macroautophagy is called aggrephagy. Here we review the processes of aggregate formation, recognition, transport, and sequestration into autophagosomes by autophagy receptors and the role of aggrephagy in different protein aggregation diseases.http://dx.doi.org/10.1155/2012/736905 |
| spellingShingle | Trond Lamark Terje Johansen Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy International Journal of Cell Biology |
| title | Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy |
| title_full | Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy |
| title_fullStr | Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy |
| title_full_unstemmed | Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy |
| title_short | Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy |
| title_sort | aggrephagy selective disposal of protein aggregates by macroautophagy |
| url | http://dx.doi.org/10.1155/2012/736905 |
| work_keys_str_mv | AT trondlamark aggrephagyselectivedisposalofproteinaggregatesbymacroautophagy AT terjejohansen aggrephagyselectivedisposalofproteinaggregatesbymacroautophagy |