Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy
Dizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of u...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/7287180 |
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| author | Myung-Whan Suh Jaihwan Hyun Ah-Ra Lyu Dong Woon Kim Sung Jae Park Jin Woong Choi Gang Min Hur Yong-Ho Park |
| author_facet | Myung-Whan Suh Jaihwan Hyun Ah-Ra Lyu Dong Woon Kim Sung Jae Park Jin Woong Choi Gang Min Hur Yong-Ho Park |
| author_sort | Myung-Whan Suh |
| collection | DOAJ |
| description | Dizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of unilateral cochleostomy on the vestibular organs over time. Twenty-seven Sprague Dawley rats underwent cochleostomy to evaluate the postoperative changes in hearing threshold, gain and symmetry of the vestibular ocular response, overall balance function, number of hair cells in the crista, and the c-Fos activity in the brainstem vestibular nucleus. Loss of vestibular function was observed during the early stages, but function recovered partially over time. Histopathological findings demonstrated a mild decrease in vestibular hair cells numbers. Increased c-Fos immunoreactivity in the vestibular nucleus, observed in the early stages after cochleostomy, decreased over time. Cochleostomy is a risk factor for peripheral vestibular organ damage that can cause functional impairment in the peripheral vestibular organs. Altered vestibular nucleus activity may be associated with vestibular compensation and plasticity after unilateral cochleostomy. |
| format | Article |
| id | doaj-art-d76c1025b3484d67a72fdb499c8ad305 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-d76c1025b3484d67a72fdb499c8ad3052025-02-03T05:53:36ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/72871807287180Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral CochleostomyMyung-Whan Suh0Jaihwan Hyun1Ah-Ra Lyu2Dong Woon Kim3Sung Jae Park4Jin Woong Choi5Gang Min Hur6Yong-Ho Park7Department of Otorhinolaryngology, Seoul National University Hospital, Seoul 03080, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan 31116, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Anatomy, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Pharmacology, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 34134, Republic of KoreaDizziness and vertigo frequently occur after cochlear implantation (CI) surgery, particularly during the early stages. It could recover over time but some of the patients suffered from delayed or sustained vestibular symptoms after CI. This study used rat animal models to investigate the effect of unilateral cochleostomy on the vestibular organs over time. Twenty-seven Sprague Dawley rats underwent cochleostomy to evaluate the postoperative changes in hearing threshold, gain and symmetry of the vestibular ocular response, overall balance function, number of hair cells in the crista, and the c-Fos activity in the brainstem vestibular nucleus. Loss of vestibular function was observed during the early stages, but function recovered partially over time. Histopathological findings demonstrated a mild decrease in vestibular hair cells numbers. Increased c-Fos immunoreactivity in the vestibular nucleus, observed in the early stages after cochleostomy, decreased over time. Cochleostomy is a risk factor for peripheral vestibular organ damage that can cause functional impairment in the peripheral vestibular organs. Altered vestibular nucleus activity may be associated with vestibular compensation and plasticity after unilateral cochleostomy.http://dx.doi.org/10.1155/2016/7287180 |
| spellingShingle | Myung-Whan Suh Jaihwan Hyun Ah-Ra Lyu Dong Woon Kim Sung Jae Park Jin Woong Choi Gang Min Hur Yong-Ho Park Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy Neural Plasticity |
| title | Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy |
| title_full | Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy |
| title_fullStr | Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy |
| title_full_unstemmed | Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy |
| title_short | Compensation of Vestibular Function and Plasticity of Vestibular Nucleus after Unilateral Cochleostomy |
| title_sort | compensation of vestibular function and plasticity of vestibular nucleus after unilateral cochleostomy |
| url | http://dx.doi.org/10.1155/2016/7287180 |
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