A pH-Sensitive Glutathione Responsive Small-Molecule Probe TZ2 Sensitizes Lung Cancer Cells to Chemotherapy by Targeting Tumor Microenvironment

A pH-Sensitive Glutathione Responsive Small-Molecule Probe TZ2 Sensitizes Lung Cancer Cells to Chemotherapy by Targeting Tumor Microenvironment

The tumor microenvironment plays an important role in tumor incidence, metastasis, and chemotherapy resistance. Novel therapeutic strategies targeting the tumor microenvironment have become a research focus in the field of biomedicine. In this study, we developed a smart small-molecule probe, <b&...

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Bibliographic Details
Main Authors: Changle Zhong, Minghan Lu, Guanhao Pan, Xintong You, Yan Peng, Shulan Zeng, Guohai Zhang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
tumor microenvironment
pH/GSH dual-responsive characteristics
drug resistance
Online Access:https://www.mdpi.com/1420-3049/30/15/3081
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