Edaravone Dexborneol provides neuroprotective effect by inhibiting neurotoxic activation of astrocytes through inhibiting NF-κB signaling in cortical ischemia

Edaravone Dexborneol provides neuroprotective effect by inhibiting neurotoxic activation of astrocytes through inhibiting NF-κB signaling in cortical ischemia

Edaravone Dexborneol (EDB), comprised of edaravone and (+)- bornel, has been demonstrated to have synergistic effects of antioxidant and anti-inflammatory, which makes it to be applied for stroke as a protectant. However, the underlying mechanism of neuroprotection of EDB has not been fully elucidat...

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Main Authors: Zhe Chen, Tao Li, Hai-Bin Tang, Zi-Wei Lu, Zi-Yi Chen, Zhi-Hong Zhao, Xue-Ling Yang, Li-Li Zhao, Mei-Juan Dang, Ye Li, Wen-Xian Li, Xiao-Juan Wang, Peng-Peng Jiang, Shu-Qin Zhan, Gui-Lian Zhang, Hong Fan
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Brain Research Bulletin
Subjects:
Edaravone Dexborneol
Neurotoxic astrocytes
Cortical ischemia
Neuroprotection
Astrocytic polarization
Neuroprotective modulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024002314
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