Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer
Abstract Aim of this study was to proof the concept of optimizing the contrast between prostate cancer (PC) and healthy tissue by DWI post-processing using a quadrature method. DWI post-processing was performed on 30 patients (median age 67 years, prostate specific antigen 8.0 ng/ml) with PC and cle...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-86068-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571757816446976 |
|---|---|
| author | Birte Valentin Lars Schimmöller Matthias Boschheidgen Tim Ullrich Thomas Andreas Thiel Alexandra Ljimani Jan Philipp Radtke Thomas Benkert Peter Albers Gerald Antoch Hans-Jörg Wittsack Michael Quentin |
| author_facet | Birte Valentin Lars Schimmöller Matthias Boschheidgen Tim Ullrich Thomas Andreas Thiel Alexandra Ljimani Jan Philipp Radtke Thomas Benkert Peter Albers Gerald Antoch Hans-Jörg Wittsack Michael Quentin |
| author_sort | Birte Valentin |
| collection | DOAJ |
| description | Abstract Aim of this study was to proof the concept of optimizing the contrast between prostate cancer (PC) and healthy tissue by DWI post-processing using a quadrature method. DWI post-processing was performed on 30 patients (median age 67 years, prostate specific antigen 8.0 ng/ml) with PC and clear MRI findings (PI-RADS 4 and 5). Multiparametric MRI was performed at 3 Tesla. A multi-shot readout segmentation (rs-EPI) plus zoomed single-shot imaging (z-EPI) sequence was used in 15 patients (group 1) and a single-shot echo-planar imaging (ss-EPI) plus rs-EPI sequence in 15 patients (group 2). B-value images (b1000 and b1800/2000) were squared and then evaluated objectively software-based and subjectively using a 5-point. The squared DWI technique showed a significantly higher contrast ratio (CR) for ss-EPI b1800 (p < 0.001), rs-EPI b1000 (p < 0.001), rs-EPI b1800 (p < 0.001), z-EPI b1000 (p = 0.008) and for z-EPI b2000 (p < 0.001). After post-processing, a significant improvement in the subjective assessment of image quality was observed for rs-EPI b1000 (p < 0.001), rs-EPI b1800 (p < 0.001) and z-EPI b1000 (p < 0.001). The application of the square post-processing to DWI results in a significant improvement in the CR between PC and healthy tissue, especially at high b-values of ss-EPI or re-EPI. This method may help to improve the detection and differentiation of PC lesions. |
| format | Article |
| id | doaj-art-d752ba2094744a40bcc287080847d0de |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d752ba2094744a40bcc287080847d0de2025-02-02T12:20:32ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-025-86068-xSquared diffusion-weighted imaging for improving the detection of clinically significant prostate cancerBirte Valentin0Lars Schimmöller1Matthias Boschheidgen2Tim Ullrich3Thomas Andreas Thiel4Alexandra Ljimani5Jan Philipp Radtke6Thomas Benkert7Peter Albers8Gerald Antoch9Hans-Jörg Wittsack10Michael Quentin11 Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Urology, Medical Faculty, University DusseldorfMR Application Predevelopment, Siemens Healthineers AG Department of Urology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf Department of Diagnostic and Interventional Radiology, Medical Faculty, University DusseldorfAbstract Aim of this study was to proof the concept of optimizing the contrast between prostate cancer (PC) and healthy tissue by DWI post-processing using a quadrature method. DWI post-processing was performed on 30 patients (median age 67 years, prostate specific antigen 8.0 ng/ml) with PC and clear MRI findings (PI-RADS 4 and 5). Multiparametric MRI was performed at 3 Tesla. A multi-shot readout segmentation (rs-EPI) plus zoomed single-shot imaging (z-EPI) sequence was used in 15 patients (group 1) and a single-shot echo-planar imaging (ss-EPI) plus rs-EPI sequence in 15 patients (group 2). B-value images (b1000 and b1800/2000) were squared and then evaluated objectively software-based and subjectively using a 5-point. The squared DWI technique showed a significantly higher contrast ratio (CR) for ss-EPI b1800 (p < 0.001), rs-EPI b1000 (p < 0.001), rs-EPI b1800 (p < 0.001), z-EPI b1000 (p = 0.008) and for z-EPI b2000 (p < 0.001). After post-processing, a significant improvement in the subjective assessment of image quality was observed for rs-EPI b1000 (p < 0.001), rs-EPI b1800 (p < 0.001) and z-EPI b1000 (p < 0.001). The application of the square post-processing to DWI results in a significant improvement in the CR between PC and healthy tissue, especially at high b-values of ss-EPI or re-EPI. This method may help to improve the detection and differentiation of PC lesions.https://doi.org/10.1038/s41598-025-86068-x |
| spellingShingle | Birte Valentin Lars Schimmöller Matthias Boschheidgen Tim Ullrich Thomas Andreas Thiel Alexandra Ljimani Jan Philipp Radtke Thomas Benkert Peter Albers Gerald Antoch Hans-Jörg Wittsack Michael Quentin Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer Scientific Reports |
| title | Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer |
| title_full | Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer |
| title_fullStr | Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer |
| title_full_unstemmed | Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer |
| title_short | Squared diffusion-weighted imaging for improving the detection of clinically significant prostate cancer |
| title_sort | squared diffusion weighted imaging for improving the detection of clinically significant prostate cancer |
| url | https://doi.org/10.1038/s41598-025-86068-x |
| work_keys_str_mv | AT birtevalentin squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT larsschimmoller squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT matthiasboschheidgen squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT timullrich squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT thomasandreasthiel squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT alexandraljimani squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT janphilippradtke squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT thomasbenkert squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT peteralbers squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT geraldantoch squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT hansjorgwittsack squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer AT michaelquentin squareddiffusionweightedimagingforimprovingthedetectionofclinicallysignificantprostatecancer |