PTBP1介导长链非编码RNA RP11-879F14.2发挥抑制心肌纤维化的作用
目的研究长链非编码RNA(lncRNA)RP11-879F14.2调控心肌成纤维细胞纤维化表型的作用及机制。方法对心衰患者及健康对照者心肌组织进行Masson染色检测心肌胶原水平。lncRNA表达谱芯片检测心衰患者及健康对照者心肌中lncRNAs的表达变化,实时定量荧光PCR(RT-qPCR)验证RP11-879F14.2在心衰患者心肌中的表达。利用重组RP11-879F14.2腺病毒(rAd-RP11-879F14.2)感染人心房肌成纤维细胞(HAFs),检测纤维化相关基因<italic>Col1a1</italic>,<italic>Col3a1<...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2021-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
Subjects: | |
Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43496117/ |
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