Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants
The objective of this study was to screen extracts of twenty Eastern European medicinal plants, using wild-type and reporter Chromobacterium violaceum bioassays, for novel components that target bacterial cells and their quorum sensing (QS) communication systems. Three types of activity and their co...
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Sciendo
2014-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0019/acph-2014-0019.xml?format=INT |
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| author | Tolmacheva Anna A. Rogozhin Eugene A. Deryabin Dmitry G. |
| author_facet | Tolmacheva Anna A. Rogozhin Eugene A. Deryabin Dmitry G. |
| author_sort | Tolmacheva Anna A. |
| collection | DOAJ |
| description | The objective of this study was to screen extracts of twenty Eastern European medicinal plants, using wild-type and reporter Chromobacterium violaceum bioassays, for novel components that target bacterial cells and their quorum sensing (QS) communication systems. Three types of activity and their combinations were revealed: (i) direct antimicrobial growth-inhibitory activity, (ii) non-specific and specific pro-QS activities, (iii) anti-QS activity. Among seven plant extracts showing direct growth-inhibitory activity, the strongest effect was shown by Arctostaphylos uva- -ursi (bearberry) leaves. Many plants stimulated violacein production by wild-type C. violaceum ATCC 31532 in a non-specific manner, and only the herb Bidens tripartita (three-lobe beggarticks) contained compounds that mimic acyl-homoserine lactone and operated as a QS agonist. Anti-QS activity was found in eleven plants including Quercus robur (oak) cortex, Betula verrucosa (birch) buds and Eucalyptus viminalis (Manna Gum) leaves. Subsequent statistical analysis showed differences between antimicrobial and anti-QS activities, whereas both activities were defined by phylogenetic position of medical resource plant. Finally, extract from Quercus robur cortex revealed at least two fractions, showing different anti-QS mechanisms. These data confirm that multicomponent anti-infectious mechanisms are used by plants, which may be useful for drug development |
| format | Article |
| id | doaj-art-d73b9079b0ba4469b8204533c966776e |
| institution | Kabale University |
| issn | 1330-0075 1846-9558 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-d73b9079b0ba4469b8204533c966776e2025-02-02T17:22:07ZengSciendoActa Pharmaceutica1330-00751846-95582014-06-0164217318610.2478/acph-2014-0019acph-2014-0019Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plantsTolmacheva Anna A.0Rogozhin Eugene A.1Deryabin Dmitry G.2Department of Microbiology Orenburg State University 460018 Orenburg, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences Moscow, RussiaDepartment of Microbiology Orenburg State University 460018 Orenburg, RussiaThe objective of this study was to screen extracts of twenty Eastern European medicinal plants, using wild-type and reporter Chromobacterium violaceum bioassays, for novel components that target bacterial cells and their quorum sensing (QS) communication systems. Three types of activity and their combinations were revealed: (i) direct antimicrobial growth-inhibitory activity, (ii) non-specific and specific pro-QS activities, (iii) anti-QS activity. Among seven plant extracts showing direct growth-inhibitory activity, the strongest effect was shown by Arctostaphylos uva- -ursi (bearberry) leaves. Many plants stimulated violacein production by wild-type C. violaceum ATCC 31532 in a non-specific manner, and only the herb Bidens tripartita (three-lobe beggarticks) contained compounds that mimic acyl-homoserine lactone and operated as a QS agonist. Anti-QS activity was found in eleven plants including Quercus robur (oak) cortex, Betula verrucosa (birch) buds and Eucalyptus viminalis (Manna Gum) leaves. Subsequent statistical analysis showed differences between antimicrobial and anti-QS activities, whereas both activities were defined by phylogenetic position of medical resource plant. Finally, extract from Quercus robur cortex revealed at least two fractions, showing different anti-QS mechanisms. These data confirm that multicomponent anti-infectious mechanisms are used by plants, which may be useful for drug developmenthttp://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0019/acph-2014-0019.xml?format=INTmedicinal plantsantimicrobial activityquorum sensingChromobacterium violaceum bioassay |
| spellingShingle | Tolmacheva Anna A. Rogozhin Eugene A. Deryabin Dmitry G. Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants Acta Pharmaceutica medicinal plants antimicrobial activity quorum sensing Chromobacterium violaceum bioassay |
| title | Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants |
| title_full | Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants |
| title_fullStr | Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants |
| title_full_unstemmed | Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants |
| title_short | Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants |
| title_sort | antibacterial and quorum sensing regulatory activities of some traditional eastern european medicinal plants |
| topic | medicinal plants antimicrobial activity quorum sensing Chromobacterium violaceum bioassay |
| url | http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0019/acph-2014-0019.xml?format=INT |
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