The polyphenol metabolite urolithin A suppresses myostatin expression and augments glucose uptake in human skeletal muscle cells

The polyphenol metabolite urolithin A suppresses myostatin expression and augments glucose uptake in human skeletal muscle cells

Abstract Purpose Polyphenolic plant extracts have demonstrated anti-inflammatory and anti-catabolic effects in vitro, however their meaningful translation into humans remains elusive. Urolithin A (UA), a gut-derived metabolite of ellagitannins, has shown promise for improving muscle function and met...

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Bibliographic Details
Main Authors: Andrew Wilhelmsen, Leonidas G Karagounis, Andrew J. Bennett, Davide D’Amico, Andréane M. Fouassier, Simon W. Jones, Kostas Tsintzas
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Nutrition & Metabolism
Subjects:
Insulin sensitivity
Anabolic sensitivity
Skeletal muscle
Primary human myotubes
Urolithin A
Online Access:https://doi.org/10.1186/s12986-025-00909-0
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https://doi.org/10.1186/s12986-025-00909-0

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