Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process
The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Try...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6668739 |
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| author | José Rodrigues do Carmo Neto Yarlla Loyane Lira Braga Arthur Wilson Florêncio da Costa Fernanda Hélia Lucio Thais Cardoso do Nascimento Marlene Antônia dos Reis Mara Rubia Nunes Celes Flávia Aparecida de Oliveira Juliana Reis Machado Marcos Vinícius da Silva |
| author_facet | José Rodrigues do Carmo Neto Yarlla Loyane Lira Braga Arthur Wilson Florêncio da Costa Fernanda Hélia Lucio Thais Cardoso do Nascimento Marlene Antônia dos Reis Mara Rubia Nunes Celes Flávia Aparecida de Oliveira Juliana Reis Machado Marcos Vinícius da Silva |
| author_sort | José Rodrigues do Carmo Neto |
| collection | DOAJ |
| description | The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Trypanosoma cruzi. Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between T. cruzi infection and immune, endocrine, and neurological system changes. |
| format | Article |
| id | doaj-art-d7169c37a3ef4abba4bc09b2d0d2251b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d7169c37a3ef4abba4bc09b2d0d2251b2025-02-03T01:10:53ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/66687396668739Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory ProcessJosé Rodrigues do Carmo Neto0Yarlla Loyane Lira Braga1Arthur Wilson Florêncio da Costa2Fernanda Hélia Lucio3Thais Cardoso do Nascimento4Marlene Antônia dos Reis5Mara Rubia Nunes Celes6Flávia Aparecida de Oliveira7Juliana Reis Machado8Marcos Vinícius da Silva9Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of General Pathology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, BrazilDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilDepartment of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, BrazilThe association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. However, many other components play essential roles, both in the long-term progression and control of the clinical status of patients infected with Trypanosoma cruzi. Components such as neuronal subpopulations, enteric glial cells, mast cells and their proteases, and homeostasis-related proteins from several organic systems (serotonin and galectins) are differentially involved in the progression of Chagasic megacolon. This review is aimed at revealing the characteristics of the intestinal microenvironment found in Chagasic megacolon by using different types of already used biomarkers. Information regarding these components may provide new therapeutic alternatives and improve the understanding of the association between T. cruzi infection and immune, endocrine, and neurological system changes.http://dx.doi.org/10.1155/2021/6668739 |
| spellingShingle | José Rodrigues do Carmo Neto Yarlla Loyane Lira Braga Arthur Wilson Florêncio da Costa Fernanda Hélia Lucio Thais Cardoso do Nascimento Marlene Antônia dos Reis Mara Rubia Nunes Celes Flávia Aparecida de Oliveira Juliana Reis Machado Marcos Vinícius da Silva Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process Journal of Immunology Research |
| title | Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process |
| title_full | Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process |
| title_fullStr | Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process |
| title_full_unstemmed | Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process |
| title_short | Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process |
| title_sort | biomarkers and their possible functions in the intestinal microenvironment of chagasic megacolon an overview of the neuro inflammatory process |
| url | http://dx.doi.org/10.1155/2021/6668739 |
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